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Am J Clin Nutr. 2017 Aug;106(2):568-580. doi: 10.3945/ajcn.116.140962. Epub 2017 Jun 28.

Infant feeding and growth trajectory patterns in childhood and body composition in young adulthood.

Author information

1
Division of Metabolic and Nutritional Medicine, and.
2
Menzies Institute for Medical Research, The University of Tasmania, Hobart, Tasmania, Australia; wendy.oddy@utas.edu.au.
3
Telethon Kids Institute and.
4
Department of Paediatrics, Leiden University Medical Center, Leiden, Netherlands.
5
School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
6
Department of Paediatrics, Medical University of Warsaw, Warsaw, Poland; and.
7
Institute of Gastroenterology, Nutrition and Liver Disease, Schneider Children's Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
8
Division of Gastroenterology and Hepatology, Dr. von Hauner Children's Hospital, Ludwig-Maximilians Universität München, Munich, Germany.

Abstract

Background: Growth patterns of breastfed and formula-fed infants may differ, with formula-fed infants growing more rapidly than breastfed infants into childhood and adulthood.Objective: Our objectives were to identify growth patterns and investigate early nutritional programming potential on growth patterns at 6 y and on body composition at 20 y.Design: The West Australian Pregnancy Cohort (Raine) Study and 3 European cohort studies (European Childhood Obesity Trial, Norwegian Human Milk Study, and Prevention of Coeliac Disease) that collaborate in the European Union-funded Early Nutrition project combined, harmonized, and pooled data on full breastfeeding, anthropometry, and body composition. Latent growth mixture modeling was applied to identify growth patterns among the 6708 individual growth trajectories. The association of full breastfeeding for <3 mo compared with ≥3 mo with the identified trajectory classes was assessed by logistic regression. Differences in body composition at 20 y among the identified trajectory classes were tested by analysis of variance.Results: Three body mass index (BMI; in kg/m2) trajectory patterns were identified and labeled as follows-class 1: persistent, accelerating, rapid growth (5%); class 2: early, nonpersistent, rapid growth (40%); and class 3: normative growth (55%). A shorter duration of full breastfeeding for <3 mo was associated with being in rapid-growth class 1 (OR: 2.66; 95% CI: 1.48, 4.79) and class 2 (OR: 1.96; 95% CI: 1.51, 2.55) rather than the normative-growth class 3 after adjustment for covariates. Both rapid-growth classes showed significant associations with body composition at 20 y (P < 0.0001).Conclusions: Full breastfeeding for <3 mo compared with ≥3 mo may be associated with rapid growth in early childhood and body composition in young adulthood. Rapid-growth patterns in early childhood could be a mediating link between infant feeding and long-term obesity risk.

KEYWORDS:

BMI; European Childhood Obesity Prevention trial; Norwegian Human Milk Study; Prevention of Coeliac Disease; Project Early Nutrition; Western Australian Pregnancy Cohort (Raine) Study; body composition; breastfeeding; growth patterns; longitudinal

PMID:
28659295
DOI:
10.3945/ajcn.116.140962
[Indexed for MEDLINE]

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