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1994 1
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2010 1
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2015 1
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2019 2
2020 5
2021 2
2023 2
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WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication.
Park EM, Scott PM, Clutario K, Cassidy KB, Zhan K, Gerber SA, Holland AJ. Park EM, et al. J Cell Biol. 2020 Jan 6;219(1):e201904203. doi: 10.1083/jcb.201904203. Epub 2019 Dec 24. J Cell Biol. 2020. PMID: 31874114 Free PMC article.
A previous genome-wide screen revealed that depletion of 14 RNA splicing factors leads to a specific defect in centriole duplication, but the cause of this deficit remains unknown. Here, we identified an additional pre-mRNA splicing factor, WBP11, as a novel protein requir …
A previous genome-wide screen revealed that depletion of 14 RNA splicing factors leads to a specific defect in centriole duplication, but th …
Heterozygous loss of WBP11 function causes multiple congenital defects in humans and mice.
Martin EMMA, Enriquez A, Sparrow DB, Humphreys DT, McInerney-Leo AM, Leo PJ, Duncan EL, Iyer KR, Greasby JA, Ip E, Giannoulatou E, Sheng D, Wohler E, Dimartino C, Amiel J, Capri Y, Lehalle D, Mory A, Wilnai Y, Lebenthal Y, Gharavi AG, Krzemień GG, Miklaszewska M, Steiner RD, Raggio C, Blank R, Baris Feldman H, Milo Rasouly H, Sobreira NLM, Jobling R, Gordon CT, Giampietro PF, Dunwoodie SL, Chapman G. Martin EMMA, et al. Hum Mol Genet. 2020 Dec 4;29(22):3662-3678. doi: 10.1093/hmg/ddaa258. Hum Mol Genet. 2020. PMID: 33276377 Free PMC article.
We generated a Wbp11 null allele in mouse using CRISPR-Cas9 targeting. Wbp11 homozygous null embryos die prior to E8.5, indicating that Wbp11 is essential for development. Fewer Wbp11 heterozygous null mice are found than expected due to embryonic and …
We generated a Wbp11 null allele in mouse using CRISPR-Cas9 targeting. Wbp11 homozygous null embryos die prior to E8.5, indica …
Identification and verification of diagnostic biomarkers in recurrent pregnancy loss via machine learning algorithm and WGCNA.
Wei C, Wei Y, Cheng J, Tan X, Zhou Z, Lin S, Pang L. Wei C, et al. Front Immunol. 2023 Aug 25;14:1241816. doi: 10.3389/fimmu.2023.1241816. eCollection 2023. Front Immunol. 2023. PMID: 37691920 Free PMC article.
The turquoise module, which showed the highest relevance to clinical symptoms based on WGCNA results, contained 104 DEGs. Three hub genes, WBP11, ACTR2, and NCSTN, were identified using machine learning algorithms. ROC curves demonstrated a strong diagnostic value when the …
The turquoise module, which showed the highest relevance to clinical symptoms based on WGCNA results, contained 104 DEGs. Three hub genes, …
The splicing factor WBP11 mediates MCM7 intron retention to promote the malignant progression of ovarian cancer.
Wei Y, Chen Z, Li Y, Song K. Wei Y, et al. Oncogene. 2024 Apr 1. doi: 10.1038/s41388-024-03015-2. Online ahead of print. Oncogene. 2024. PMID: 38561505
Furthermore, FOXM1 transcriptionally activated WBP11 expression by directly binding to its promoter in OC cells. ...Thus, WBP11 is an oncogenic splicing factor with potential therapeutic and prognostic implications in OC....
Furthermore, FOXM1 transcriptionally activated WBP11 expression by directly binding to its promoter in OC cells. ...Thus, WBP11 …
The miR-29c-KIAA1199 axis regulates gastric cancer migration by binding with WBP11 and PTP4A3.
Wang L, Yu T, Li W, Li M, Zuo Q, Zou Q, Xiao B. Wang L, et al. Oncogene. 2019 Apr;38(17):3134-3150. doi: 10.1038/s41388-018-0642-0. Epub 2019 Jan 9. Oncogene. 2019. PMID: 30626935
In this study, we found that KIAA1199 inhibition or overexpression regulated the expression of E-cadherin and N-cadherin through KIAA1199 binding to WW domain binding protein 11 (WBP11) and protein tyrosine phosphatase type IVA, member 3 (PTP4A3) and through the subsequent …
In this study, we found that KIAA1199 inhibition or overexpression regulated the expression of E-cadherin and N-cadherin through KIAA1199 bi …
Allosteric modulation of the binding affinity between PQBP1 and the spliceosomal protein U5-15kD.
Mizuguchi M, Obita T, Kajiyama A, Kozakai Y, Nakai T, Nabeshima Y, Okazawa H. Mizuguchi M, et al. FEBS Lett. 2016 Jul;590(14):2221-31. doi: 10.1002/1873-3468.12256. Epub 2016 Jun 28. FEBS Lett. 2016. PMID: 27314904 Free article.
Polyglutamine tract-binding protein 1 (PQBP1) is an intrinsically disordered protein composed of a small folded WW domain and a long disordered region. PQBP1 binds to spliceosomal proteins WBP11 and U5-15kD through its N-terminal WW domain and C-terminal region, respective …
Polyglutamine tract-binding protein 1 (PQBP1) is an intrinsically disordered protein composed of a small folded WW domain and a long disorde …
Capturing Protein-Protein Interactions with Acidic Amino Acids Reactive Cross-Linkers.
Liao QQ, Shu X, Sun W, Mandapaka H, Xie F, Zhang Z, Dai T, Wang S, Zhao J, Jiang H, Zhang L, Lin J, Li SW, Coin I, Yang F, Peng J, Li K, Wu H, Zhou F, Yang B. Liao QQ, et al. Small. 2023 Dec 11:e2308383. doi: 10.1002/smll.202308383. Online ahead of print. Small. 2023. PMID: 38073323
The Cross-linking mass spectrometry (XL-MS) study with p53 identified 87 putative binders of the C-terminal domain of p53. Among them, SARNP, ZRAB2, and WBP11 are shown to regulate the expression and alternative splicing of p53 target genes. ...
The Cross-linking mass spectrometry (XL-MS) study with p53 identified 87 putative binders of the C-terminal domain of p53. Among them, SARNP …
A comprehensive analysis of SNPs and CNVs identifies novel markers associated with disease outcomes in colorectal cancer.
Yu Y, Werdyani S, Carey M, Parfrey P, Yilmaz YE, Savas S. Yu Y, et al. Mol Oncol. 2021 Dec;15(12):3329-3347. doi: 10.1002/1878-0261.13067. Epub 2021 Aug 5. Mol Oncol. 2021. PMID: 34309201 Free PMC article.
The Cancer Genome Atlas (TCGA) datasets were used for replication purposes and to examine the gene expression differences between tumor and nontumor tissue samples. A common SNP (WBP11-rs7314075) was associated with disease-specific survival with P-value of 3.2 10(-8) . .. …
The Cancer Genome Atlas (TCGA) datasets were used for replication purposes and to examine the gene expression differences between tumor and …
The splicing factor PQBP1 regulates mesodermal and neural development through FGF signaling.
Iwasaki Y, Thomsen GH. Iwasaki Y, et al. Development. 2014 Oct;141(19):3740-51. doi: 10.1242/dev.106658. Epub 2014 Sep 10. Development. 2014. PMID: 25209246 Free PMC article.
Here, we reveal essential roles for PQBP1 and a binding partner, WBP11, in early development of Xenopus embryos. Both genes are expressed in the nascent mesoderm and neurectoderm, and morpholino knockdown of either causes defects in differentiation and morphogenesis of the …
Here, we reveal essential roles for PQBP1 and a binding partner, WBP11, in early development of Xenopus embryos. Both genes are expre …
Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis of mRNA splicing relevant proteins in aging HSPCs.
Lian X, Zhao M, Xia J, He Y, Zhang L. Lian X, et al. Aging Clin Exp Res. 2021 Nov;33(11):3123-3134. doi: 10.1007/s40520-020-01509-z. Epub 2020 Mar 5. Aging Clin Exp Res. 2021. PMID: 32141009
We found that not only the notable mRNA splicing genes such as SR, hnRNP, WBP11, Sf3b1, Ptbp1 and U2AF1 but also the scarcely reported mRNA splicing relevant genes such as Rbmxl1, Dhx16, Pcbp2, Pabpc1 were significantly down-regulated. ...
We found that not only the notable mRNA splicing genes such as SR, hnRNP, WBP11, Sf3b1, Ptbp1 and U2AF1 but also the scarcely reporte …
24 results