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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1993 1
1994 1
1995 1
1999 3
2000 1
2001 5
2002 3
2003 1
2004 7
2005 8
2006 8
2007 6
2008 19
2009 12
2010 21
2011 26
2012 19
2013 26
2014 24
2015 22
2016 24
2017 21
2018 18
2019 31
2020 25
2021 33
2022 32
2023 31
2024 9

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396 results

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Page 1
Motion of VAPB molecules reveals ER-mitochondria contact site subdomains.
Obara CJ, Nixon-Abell J, Moore AS, Riccio F, Hoffman DP, Shtengel G, Xu CS, Schaefer K, Pasolli HA, Masson JB, Hess HF, Calderon CP, Blackstone C, Lippincott-Schwartz J. Obara CJ, et al. Nature. 2024 Feb;626(7997):169-176. doi: 10.1038/s41586-023-06956-y. Epub 2024 Jan 24. Nature. 2024. PMID: 38267577 Free PMC article.
Here we combine three-dimensional electron microscopy with high-speed molecular tracking of a model organelle tether, Vesicle-associated membrane protein (VAMP)-associated protein B (VAPB), to map the structure and diffusion landscape of ERMCSs. We uncovered dynamic subdom …
Here we combine three-dimensional electron microscopy with high-speed molecular tracking of a model organelle tether, Vesicle-associated mem …
Mutant VAPB: Culprit or Innocent Bystander of Amyotrophic Lateral Sclerosis?
Borgese N, Navone F, Nukina N, Yamanaka T. Borgese N, et al. Contact (Thousand Oaks). 2021 Jun 15;4:25152564211022515. doi: 10.1177/25152564211022515. eCollection 2021 Jan-Dec. Contact (Thousand Oaks). 2021. PMID: 37366377 Free PMC article. Review.
Nearly twenty years ago a mutation in the VAPB gene, resulting in a proline to serine substitution (p.P56S), was identified as the cause of a rare, slowly progressing, familial form of the motor neuron degenerative disease Amyotrophic Lateral Sclerosis (ALS). ...In light o …
Nearly twenty years ago a mutation in the VAPB gene, resulting in a proline to serine substitution (p.P56S), was identified as the ca …
VAPB-mediated ER-targeting stabilizes IRS-1 signalosomes to regulate insulin/IGF signaling.
Gao XK, Sheng ZK, Lu YH, Sun YT, Rao XS, Shi LJ, Cong XX, Chen X, Wu HB, Huang M, Zheng Q, Guo JS, Jiang LJ, Zheng LL, Zhou YT. Gao XK, et al. Cell Discov. 2023 Aug 1;9(1):83. doi: 10.1038/s41421-023-00576-6. Cell Discov. 2023. PMID: 37528084 Free PMC article.
VAPB mainly binds active IRS-1 because IGF-1 enhanced the VAPB-IRS-1 association and replacing of the nine tyrosine residues of YXXM motifs disrupted the VAPB-IRS-1 association. We further delineated that the Y745 and Y746 residues in the FFAT-like motif of I …
VAPB mainly binds active IRS-1 because IGF-1 enhanced the VAPB-IRS-1 association and replacing of the nine tyrosine residues o …
Neurodegeneration-associated protein VAPB regulates proliferation in medulloblastoma.
Faria Assoni A, Giove Mitsugi T, Wardenaar R, Oliveira Ferreira R, Farias Jandrey EH, Machado Novaes G, Fonseca de Oliveira Granha I, Bakker P, Kaid C, Zatz M, Foijer F, Keith Okamoto O. Faria Assoni A, et al. Sci Rep. 2023 Nov 9;13(1):19481. doi: 10.1038/s41598-023-45319-5. Sci Rep. 2023. PMID: 37945695 Free PMC article.
Knockout of VAPB (VAPB(KO)) delayed cell cycle progression. Furthermore, transcript levels of WNT-related proteins were decreased in the VAPB(KO). We conclude that VAPB is required for proliferation of medulloblastoma cells, thus revealing VAPB …
Knockout of VAPB (VAPB(KO)) delayed cell cycle progression. Furthermore, transcript levels of WNT-related proteins were decrea …
The Link between VAPB Loss of Function and Amyotrophic Lateral Sclerosis.
Borgese N, Iacomino N, Colombo SF, Navone F. Borgese N, et al. Cells. 2021 Jul 23;10(8):1865. doi: 10.3390/cells10081865. Cells. 2021. PMID: 34440634 Free PMC article. Review.
Instead, loss-of-function of the single wild-type allele is required for pathological effects, and VAPB haploinsufficiency may be the main driver of the disease. In this article, we review the studies on the effects of VAPB deficit in cellular and animal models. Sev …
Instead, loss-of-function of the single wild-type allele is required for pathological effects, and VAPB haploinsufficiency may be the …
VAPB ER-Aggregates, A Possible New Biomarker in ALS Pathology.
Cadoni MPL, Biggio ML, Arru G, Secchi G, Orrù N, Clemente MG, Sechi G, Yamoah A, Tripathi P, Orrù S, Manetti R, Galleri G. Cadoni MPL, et al. Cells. 2020 Jan 9;9(1):164. doi: 10.3390/cells9010164. Cells. 2020. PMID: 31936602 Free PMC article.
This specific pattern led us to suppose that VAPB could be misfolded in sALS. The data indirectly confirmed by flow cytometry assay (FCA) showed a reduction of VAPB fluorescent signals in sALS. However, our observations were not associated with the presence of a gen …
This specific pattern led us to suppose that VAPB could be misfolded in sALS. The data indirectly confirmed by flow cytometry assay ( …
Amyotrophic Lateral Sclerosis Overview.
Siddique N, Siddique T. Siddique N, et al. 2001 Mar 23 [updated 2023 Sep 28]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2001 Mar 23 [updated 2023 Sep 28]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301623 Free Books & Documents. Review.
Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases.
Mao H, Chen W, Chen L, Li L. Mao H, et al. Biochem Pharmacol. 2022 May;199:115011. doi: 10.1016/j.bcp.2022.115011. Epub 2022 Mar 18. Biochem Pharmacol. 2022. PMID: 35314166 Review.
A large number of studies indicate that many proteins are involved in the formation of MAMs, including dynamic-related protein 1 (Drp1), DJ-1, PTEN-induced putative kinase 1 (PINK), alpha-synuclein (alpha-syn), sigma-1 receptor (S1R), mitofusin-2 (Mfn2), presenilin-1 (PS1), prote …
A large number of studies indicate that many proteins are involved in the formation of MAMs, including dynamic-related protein 1 (Drp1), DJ- …
Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca(2+) and synaptic defects.
Markovinovic A, Martín-Guerrero SM, Mórotz GM, Salam S, Gomez-Suaga P, Paillusson S, Greig J, Lee Y, Mitchell JC, Noble W, Miller CCJ. Markovinovic A, et al. Acta Neuropathol Commun. 2024 Feb 23;12(1):32. doi: 10.1186/s40478-024-01742-x. Acta Neuropathol Commun. 2024. PMID: 38395965 Free PMC article.
We show that overexpression of VAPB or PTPIP51 to enhance ER-mitochondria signaling corrects mutant TDP43 induced damage to inositol 1,4,5-trisphosphate (IP3) receptor delivery of Ca(2+) to mitochondria which is a primary function of the VAPB-PTPIP51 tethers, and to …
We show that overexpression of VAPB or PTPIP51 to enhance ER-mitochondria signaling corrects mutant TDP43 induced damage to inositol …
ARTC1-mediated VAPB ADP-ribosylation regulates calcium homeostasis.
Ma X, Li M, Liu Y, Zhang X, Yang X, Wang Y, Li Y, Wang J, Liu X, Yan Z, Yu X, Wu C. Ma X, et al. J Mol Cell Biol. 2024 Jan 5;15(7):mjad043. doi: 10.1093/jmcb/mjad043. J Mol Cell Biol. 2024. PMID: 37381178 Free PMC article.
We also identified vesicle-associated membrane protein-associated protein B (VAPB) as a new target of hARTC1 and pinpointed Arg50 of VAPB as the ADP-ribosylation site. Furthermore, we demonstrated that knockdown of hARTC1 impaired intracellular calcium homeostasis, …
We also identified vesicle-associated membrane protein-associated protein B (VAPB) as a new target of hARTC1 and pinpointed Arg50 of …
396 results