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Chem Commun (Camb). 2009 Jun 7;(21):3056-8. doi: 10.1039/b823258j. Epub 2009 Apr 9.

Using aptamers evolved from cell-SELEX to engineer a molecular delivery platform.

Author information

1
Department of Chemistry and Physiology and Functional Genomics, Center for Research at the Bio/Nano interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA.

Abstract

We report a chemically modified construct of the Sgc8 aptamer, selected against CEM cells, conjugated to an activator platform for stimulated release of molecules at the tumor surface using DNA template assisted functional group transfer reactions (DTGTR).

PMID:
19462085
DOI:
10.1039/b823258j
[Indexed for MEDLINE]

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