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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 1
1991 1
1992 1
1993 1
1995 1
1996 1
1998 1
1999 1
2002 3
2003 2
2004 2
2005 1
2006 1
2008 1
2009 2
2010 1
2011 6
2013 1
2015 2
2016 1
2017 3
2022 1
2023 1
2024 1

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34 results

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Page 1
Key aspects of modern GPCR drug discovery.
Addis P, Bali U, Baron F, Campbell A, Harborne S, Jagger L, Milne G, Pearce M, Rosethorne EM, Satchell R, Swift D, Young B, Unitt JF. Addis P, et al. Among authors: unitt jf. SLAS Discov. 2024 Jan;29(1):1-22. doi: 10.1016/j.slasd.2023.08.007. Epub 2023 Aug 23. SLAS Discov. 2024. PMID: 37625784 Free article. Review.
Thermal Shift as an Entropy-Driven Effect.
Redhead M, Satchell R, McCarthy C, Pollack S, Unitt J. Redhead M, et al. Among authors: unitt j. Biochemistry. 2017 Nov 28;56(47):6187-6199. doi: 10.1021/acs.biochem.7b00860. Epub 2017 Nov 15. Biochemistry. 2017. PMID: 29111685
Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation.
Novak A, Laughton D, Lane R, Blackham E, Thomas J, Chatzopoulou E, Wrigglesworth J, Quddus A, Ahmed S, Cousin D, Duffy L, Dubois N, Unitt J, Orban K, Browne E, Ward M, Mycock D, Ieva M, Bland N, George P, Bourne T, Asnagli H, Birch L, Jones G. Novak A, et al. Among authors: unitt j. J Med Chem. 2022 Dec 22;65(24):16640-16650. doi: 10.1021/acs.jmedchem.2c01446. Epub 2022 Nov 30. J Med Chem. 2022. PMID: 36449304
Discovery of pyrazoles as novel FPR1 antagonists.
Morley AD, Cook A, King S, Roberts B, Lever S, Weaver R, Macdonald C, Unitt J, Fagura M, Phillips T, Lewis R, Wenlock M. Morley AD, et al. Among authors: unitt j. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6456-60. doi: 10.1016/j.bmcl.2011.08.085. Epub 2011 Sep 6. Bioorg Med Chem Lett. 2011. PMID: 21955939
FKBP5 mRNA Expression Is a Biomarker for GR Antagonism.
Bali U, Phillips T, Hunt H, Unitt J. Bali U, et al. Among authors: unitt j. J Clin Endocrinol Metab. 2016 Nov;101(11):4305-4312. doi: 10.1210/jc.2016-1624. Epub 2016 Jul 26. J Clin Endocrinol Metab. 2016. PMID: 27459525 Clinical Trial.
Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists.
Kindon N, Andrews G, Baxter A, Cheshire D, Hemsley P, Johnson T, Liu YZ, McGinnity D, McHale M, Mete A, Reuberson J, Roberts B, Steele J, Teobald B, Unitt J, Vaughan D, Walters I, Stocks MJ. Kindon N, et al. Among authors: unitt j. ACS Med Chem Lett. 2017 Sep 1;8(9):981-986. doi: 10.1021/acsmedchemlett.7b00315. eCollection 2017 Sep 14. ACS Med Chem Lett. 2017. PMID: 28947948 Free PMC article.
Discovery of small molecule human FPR1 receptor antagonists.
Unitt J, Fagura M, Phillips T, King S, Perry M, Morley A, MacDonald C, Weaver R, Christie J, Barber S, Mohammed R, Paul M, Cook A, Baxter A. Unitt J, et al. Bioorg Med Chem Lett. 2011 May 15;21(10):2991-7. doi: 10.1016/j.bmcl.2011.03.049. Epub 2011 Mar 21. Bioorg Med Chem Lett. 2011. PMID: 21486695
Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates.
Forbes LV, Sjögren T, Auchère F, Jenkins DW, Thong B, Laughton D, Hemsley P, Pairaudeau G, Turner R, Eriksson H, Unitt JF, Kettle AJ. Forbes LV, et al. Among authors: unitt jf. J Biol Chem. 2013 Dec 20;288(51):36636-47. doi: 10.1074/jbc.M113.507756. Epub 2013 Nov 5. J Biol Chem. 2013. PMID: 24194519 Free PMC article.
Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist.
Hunt HJ, Belanoff JK, Walters I, Gourdet B, Thomas J, Barton N, Unitt J, Phillips T, Swift D, Eaton E. Hunt HJ, et al. Among authors: unitt j. J Med Chem. 2017 Apr 27;60(8):3405-3421. doi: 10.1021/acs.jmedchem.7b00162. Epub 2017 Apr 17. J Med Chem. 2017. PMID: 28368581
34 results