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Virology. 2014 May;456-457:39-42. doi: 10.1016/j.virol.2014.03.013. Epub 2014 Mar 28.

Ultrastructural fingerprints of avian influenza A (H7N9) virus in infected human lung cells.

Author information

1
Virologie et Pathologie Humaine VirPath, EA 4610, Université Claude Bernard Lyon 1-Hospices Civils de Lyon, Lyon, France. Electronic address: olivier.terrier@univ-lyon1.fr.
2
Virologie et Pathologie Humaine VirPath, EA 4610, Université Claude Bernard Lyon 1-Hospices Civils de Lyon, Lyon, France.
3
Centre national de référence des virus influenza (région Sud), Laboratoire de Virologie Est, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Bron, France.
4
Virologie et Pathologie Humaine VirPath, EA 4610, Université Claude Bernard Lyon 1-Hospices Civils de Lyon, Lyon, France; Centre national de référence des virus influenza (région Sud), Laboratoire de Virologie Est, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Bron, France.
5
Virologie et Pathologie Humaine VirPath, EA 4610, Université Claude Bernard Lyon 1-Hospices Civils de Lyon, Lyon, France; VirNext, Faculté de Médecine RTH Laennec, Université Lyon 1, Lyon, France.
6
Virologie et Pathologie Humaine VirPath, EA 4610, Université Claude Bernard Lyon 1-Hospices Civils de Lyon, Lyon, France; VirNext, Faculté de Médecine RTH Laennec, Université Lyon 1, Lyon, France. Electronic address: manuel.rosa-calatrava@univ-lyon1.fr.

Abstract

In this study, we investigated the ultrastructural modifications induced by influenza A (H7N9) virus in human lung epithelial cells. One particular characteristic of H7N9 viral infection is the formation of numerous M1-associated striated tubular structures within the nucleus and the cytoplasm, which have only previously been observed for a limited number of influenza A viruses, notably the 2009 pandemic (H1N1) virus.

KEYWORDS:

H7N9; Host cellular ultrastructure; Infection fingerprints; Influenza virus; M1; Matrix protein; Orthomyxoviridae; Viruses

PMID:
24889223
DOI:
10.1016/j.virol.2014.03.013
[Indexed for MEDLINE]
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