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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 2
1995 2
1997 4
1998 6
1999 7
2000 20
2001 15
2002 26
2003 27
2004 24
2005 34
2006 33
2007 49
2008 44
2009 42
2010 44
2011 46
2012 76
2013 66
2014 72
2015 72
2016 62
2017 66
2018 88
2019 61
2020 60
2021 49
2022 51
2023 39
2024 19

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1,018 results

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Page 1
Associations between UGT2B7 polymorphisms and cancer susceptibility: A meta-analysis.
Shen ML, Xiao A, Yin SJ, Wang P, Lin XQ, Yu CB, He GH. Shen ML, et al. Gene. 2019 Jul 20;706:115-123. doi: 10.1016/j.gene.2019.05.025. Epub 2019 May 10. Gene. 2019. PMID: 31082503 Review.
BACKGROUND: UGT2B7 was recently acknowledged as a new critical enzyme involved in biotransformation of a variety of carcinogens, whose function was reported to be significantly associated with its encoding gene (UGT2B7) polymorphisms. However, results regarding the …
BACKGROUND: UGT2B7 was recently acknowledged as a new critical enzyme involved in biotransformation of a variety of carcinogens, whos …
UGT2B7 c.-161C>T polymorphism frequency in Croatian population.
Božina T, Karačić E, Ganoci L, Čuković-Čavka S, Palić J, Božina N, Šimičević L. Božina T, et al. Arh Hig Rada Toksikol. 2022 Dec 30;73(4):303-307. doi: 10.2478/aiht-2022-73-3663. eCollection 2022 Dec 1. Arh Hig Rada Toksikol. 2022. PMID: 36607721 Free PMC article.
This polymorphism is in complete linkage disequilibrium with the UGT2B7 c.802C>T (UGT2B7*2, rs7439366) variant, which is important in clinical medicine. ...Genotyping was performed by real-time polymerase chain reaction (PCR) using the TaqMan() Drug Metabolism Ge …
This polymorphism is in complete linkage disequilibrium with the UGT2B7 c.802C>T (UGT2B7*2, rs7439366) variant, which is im …
Effect of UGT2B7 genotypes on plasma concentration of valproic acid: a meta-analysis.
Wang P, Lin XQ, Cai WK, Xu GL, Zhou MD, Yang M, He GH. Wang P, et al. Eur J Clin Pharmacol. 2018 Apr;74(4):433-442. doi: 10.1007/s00228-017-2395-z. Epub 2017 Dec 14. Eur J Clin Pharmacol. 2018. PMID: 29243113 Review.
Recently, increasing evidence suggested that polymorphisms in UGT2B7 gene were associated with VPA pharmacokinetics, but results remained controversial. ...CONCLUSIONS: The results of this meta-analysis demonstrated that UGT2B7 G211T and C161T polymorphisms were abl …
Recently, increasing evidence suggested that polymorphisms in UGT2B7 gene were associated with VPA pharmacokinetics, but results rema …
The Human UGT2B7 Nanodisc.
Cook I, Asenjo AB, Sosa H, Leyh TS. Cook I, et al. Drug Metab Dispos. 2020 Mar;48(3):198-204. doi: 10.1124/dmd.119.089946. Epub 2019 Dec 31. Drug Metab Dispos. 2020. PMID: 31892527 Free PMC article.
Each nanodisc is shown to harbor a single UGT2B7 monomer. The methods described herein should be widely applicable to UGTs, and these findings are expected to set the stage for experimentalists to more freely explore the structure, function, and biology of this important a …
Each nanodisc is shown to harbor a single UGT2B7 monomer. The methods described herein should be widely applicable to UGTs, and these …
Arginine-259 of UGT2B7 Confers UDP-Sugar Selectivity.
Nair PC, Chau N, McKinnon RA, Miners JO. Nair PC, et al. Mol Pharmacol. 2020 Dec;98(6):710-718. doi: 10.1124/molpharm.120.000104. Epub 2020 Oct 2. Mol Pharmacol. 2020. PMID: 33008919
An investigation of UGT2B7-catalyzed morphine glycosidation indicated that glucuronidation is the principal route of metabolism because the binding affinity of UDP-GlcUA is higher than that of UDP-Glc. Currently, it is unclear which residues in the UGT2B7 cofactor b …
An investigation of UGT2B7-catalyzed morphine glycosidation indicated that glucuronidation is the principal route of metabolism becau …
The N(6)-methyladenosine modification posttranscriptionally regulates hepatic UGT2B7 expression.
Ondo K, Isono M, Nakano M, Hashiba S, Fukami T, Nakajima M. Ondo K, et al. Biochem Pharmacol. 2021 Jul;189:114402. doi: 10.1016/j.bcp.2020.114402. Epub 2020 Dec 30. Biochem Pharmacol. 2021. PMID: 33387482
By experiments using actinomycin D, an inhibitor of transcription, it was demonstrated that ALKBH5-mediated demethylation would attenuate UGT2B7 mRNA degradation, whereas METTL3/METTL14 or FTO-mediated m(6)A modification would alter the transactivity of UGT2B7. ...I …
By experiments using actinomycin D, an inhibitor of transcription, it was demonstrated that ALKBH5-mediated demethylation would attenuate …
UGT2B7 gene polymorphism and linkage disequilibrium in pediatric epileptic patients and their influence on sodium valproate monotherapy: A cohort study.
Adiga S, Pb N, Adiga U, Shenoy V. Adiga S, et al. Front Pharmacol. 2022 Sep 9;13:911827. doi: 10.3389/fphar.2022.911827. eCollection 2022. Front Pharmacol. 2022. PMID: 36160414 Free PMC article.
Results: Out of 100 patients, CC (38%), CT (43%), TT (19%) pattern was observed in UGT2B7 (C161T) gene, AA (15%), AG (39%), GG (46%) in (A268G) gene and GG (80%), GT (18%), TT (02%) in (G211T) gene. ...Conclusion: Our findings show that the genetic variation of UGT2B7 …
Results: Out of 100 patients, CC (38%), CT (43%), TT (19%) pattern was observed in UGT2B7 (C161T) gene, AA (15%), AG (39%), GG (46%) …
Pharmacogenetics of CYP2B6, CYP2A6 and UGT2B7 in HIV treatment in African populations: focus on efavirenz and nevirapine.
Čolić A, Alessandrini M, Pepper MS. Čolić A, et al. Drug Metab Rev. 2015 May;47(2):111-23. doi: 10.3109/03602532.2014.982864. Epub 2014 Nov 13. Drug Metab Rev. 2015. PMID: 25391641 Review.
This review aims to investigate ethnic variation of CYP2B6, CYP2A6 and UGT2B7, and to understand the pharmacogenetic relevance when comparing frequencies in African populations to other populations worldwide....
This review aims to investigate ethnic variation of CYP2B6, CYP2A6 and UGT2B7, and to understand the pharmacogenetic relevance when c …
Effect of UGT1A4, UGT2B7, UGT2B15, UGT2B17 and ABC1B polymorphisms on lamotrigine metabolism in Danish patients.
Petrenaite V, Öhman I, Jantzen FPT, Ekström L. Petrenaite V, et al. Epilepsy Res. 2022 May;182:106897. doi: 10.1016/j.eplepsyres.2022.106897. Epub 2022 Mar 9. Epilepsy Res. 2022. PMID: 35303539
Sex specific differences in enzyme activity (most prominent effect in women) on LTG metabolism were found for UGT2B15, UGT2B17, UGT1A4 and UGT2B7 polymorphisms. Multiple regression analysis confirmed the significant effect of OC, VPA and UGT1A4 * 2 and UGT2B7 * 2 on …
Sex specific differences in enzyme activity (most prominent effect in women) on LTG metabolism were found for UGT2B15, UGT2B17, UGT1A4 and …
Association between Food/UGT2B7 Polymorphisms and Pharmacokinetics/Pharmacodynamics Properties of Indapamide in Healthy Humans.
Abbas B, Sabri NA, El-Khouly AA. Abbas B, et al. Biomedicines. 2023 May 22;11(5):1501. doi: 10.3390/biomedicines11051501. Biomedicines. 2023. PMID: 37239171 Free PMC article.
A comparative study was performed under fasting and fed conditions to investigate the effect of food and selected single nucleotide polymorphisms in the uridine diphosphate glucuronyl transferase (UGT2B7) gene on the pharmacokinetics and pharmacodynamics behavior of indapa …
A comparative study was performed under fasting and fed conditions to investigate the effect of food and selected single nucleotide polymorp …
1,018 results