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J Dairy Res. 2016 May;83(2):256-60. doi: 10.1017/S0022029916000066. Epub 2016 Apr 1.

Mild protein hydrolysation of lactose-free milk further reduces milk-related gastrointestinal symptoms.

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Valio Ltd,R&D,P.O. Box 30,00039 Valio,Finland.


Gastrointestinal symptoms associated with milk are common. Besides lactose, milk proteins may cause symptoms in sensitive individuals. We have developed a method for mild enzymatic hydrolysation of milk proteins and studied the effects of hydrolysed milk on gastrointestinal symptoms in adults with a self-diagnosed sensitive stomach. In a double blind, randomised placebo-controlled study, 97 subjects consumed protein-hydrolysed lactose-free milk or commercially available lactose-free milk for 10 d. Frequency of gastrointestinal symptoms during the study period was reported and a symptom score was calculated. Rumbling and flatulence decreased significantly in the hydrolysed milk group (P < 0·05). Also, the total symptom score was lower in subjects who consumed hydrolysed milk (P < 0·05). No difference between groups was seen in abdominal pain (P = 0·47) or bloating (P = 0·076). The results suggest that mild enzymatic protein hydrolysation may decrease gastrointestinal symptoms in adults with a sensitive stomach.


Milk protein; enzymatic hydrolysation; gastrointestinal symptoms; human

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