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Items: 1 to 20 of 85


Characterization of Thermally Activated Metalloenediyne Cytotoxicity in Human Melanoma Cells.

Keller EJ, Porter M, Garrett JE, Varie M, Wang H, Pollok KE, Turchi JJ, Zaleski JM, Dynlacht JR.

Radiat Res. 2018 Aug;190(2):107-116. doi: 10.1667/RR15019.1. Epub 2018 May 15.


Modulating DNA Repair Pathways to Improve Precision Genome Engineering.

Pawelczak KS, Gavande NS, VanderVere-Carozza PS, Turchi JJ.

ACS Chem Biol. 2018 Feb 16;13(2):389-396. doi: 10.1021/acschembio.7b00777. Epub 2017 Dec 20.


Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction.

Gavande NS, VanderVere-Carozza P, Mishra AK, Vernon TL, Pawelczak KS, Turchi JJ.

J Med Chem. 2017 Oct 12;60(19):8055-8070. doi: 10.1021/acs.jmedchem.7b00780. Epub 2017 Sep 21.


DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer.

Sears CR, Cooney SA, Chin-Sinex H, Mendonca MS, Turchi JJ.

DNA Repair (Amst). 2016 Apr;40:35-46. doi: 10.1016/j.dnarep.2016.02.004. Epub 2016 Mar 3.


DNA repair targeted therapy: The past or future of cancer treatment?

Gavande NS, VanderVere-Carozza PS, Hinshaw HD, Jalal SI, Sears CR, Pawelczak KS, Turchi JJ.

Pharmacol Ther. 2016 Apr;160:65-83. doi: 10.1016/j.pharmthera.2016.02.003. Epub 2016 Feb 16. Review.


Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit.

Woods DS, Sears CR, Turchi JJ.

PLoS One. 2015 May 15;10(5):e0127321. doi: 10.1371/journal.pone.0127321. eCollection 2015.


Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer.

Mishra AK, Dormi SS, Turchi AM, Woods DS, Turchi JJ.

Biochem Pharmacol. 2015 Jan 1;93(1):25-33. doi: 10.1016/j.bcp.2014.10.013. Epub 2014 Nov 4.


The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer.

Fang F, Munck J, Tang J, Taverna P, Wang Y, Miller DF, Pilrose J, Choy G, Azab M, Pawelczak KS, VanderVere-Carozza P, Wagner M, Lyons J, Matei D, Turchi JJ, Nephew KP.

Clin Cancer Res. 2014 Dec 15;20(24):6504-16. doi: 10.1158/1078-0432.CCR-14-1553. Epub 2014 Oct 14.


Testing the metal of ERCC2 in predicting the response to platinum-based therapy.

Turchi JJ, Woods DS, VanderVere-Carozza P.

Cancer Discov. 2014 Oct;4(10):1118-9. doi: 10.1158/2159-8290.CD-14-0893.


Unraveling the complexities of DNA-dependent protein kinase autophosphorylation.

Neal JA, Sugiman-Marangos S, VanderVere-Carozza P, Wagner M, Turchi J, Lees-Miller SP, Junop MS, Meek K.

Mol Cell Biol. 2014 Jun;34(12):2162-75. doi: 10.1128/MCB.01554-13. Epub 2014 Mar 31.


Exploring a structural protein-drug interactome for new therapeutics in lung cancer.

Peng X, Wang F, Li L, Bum-Erdene K, Xu D, Wang B, Sinn AA, Pollok KE, Sandusky GE, Li L, Turchi JJ, Jalal SI, Meroueh SO.

Mol Biosyst. 2014 Mar 4;10(3):581-91. doi: 10.1039/c3mb70503j. Epub 2014 Jan 9.


Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma.

Xu J, Zeng LF, Shen W, Turchi JJ, Zhang ZY.

Biochem Biophys Res Commun. 2013 Oct 4;439(4):586-90. doi: 10.1016/j.bbrc.2013.09.028. Epub 2013 Sep 13.


Extracellular tissue transglutaminase activates noncanonical NF-κB signaling and promotes metastasis in ovarian cancer.

Yakubov B, Chelladurai B, Schmitt J, Emerson R, Turchi JJ, Matei D.

Neoplasia. 2013 Jun;15(6):609-19.


Chemotherapy induced DNA damage response: convergence of drugs and pathways.

Woods D, Turchi JJ.

Cancer Biol Ther. 2013 May;14(5):379-89. doi: 10.4161/cbt.23761. Epub 2013 Feb 4. Review.


Multiple protein-protein interactions within the DNA-PK complex are mediated by the C-terminus of Ku 80.

Bennett SM, Woods DS, Pawelczak KS, Turchi JJ.

Int J Biochem Mol Biol. 2012;3(1):36-45. Epub 2012 Feb 15.


Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatin.

Neher TM, Bodenmiller D, Fitch RW, Jalal SI, Turchi JJ.

Mol Cancer Ther. 2011 Oct;10(10):1796-806. doi: 10.1158/1535-7163.MCT-11-0303. Epub 2011 Aug 16.


DNA repair: from genome maintenance to biomarker and therapeutic target.

Jalal S, Earley JN, Turchi JJ.

Clin Cancer Res. 2011 Nov 15;17(22):6973-84. doi: 10.1158/1078-0432.CCR-11-0761. Epub 2011 Sep 9. Review.


Identification of Mre11 as a target for heat radiosensitization.

Dynlacht JR, Batuello CN, Lopez JT, Kim KK, Turchi JJ.

Radiat Res. 2011 Sep;176(3):323-32. Epub 2011 Jun 23.


Targeting ovarian tumor cell adhesion mediated by tissue transglutaminase.

Khanna M, Chelladurai B, Gavini A, Li L, Shao M, Courtney D, Turchi JJ, Matei D, Meroueh S.

Mol Cancer Ther. 2011 Apr;10(4):626-36. doi: 10.1158/1535-7163.MCT-10-0912. Epub 2011 Feb 17.

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