Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 75


Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening.

Lountos GT, Zhao XZ, Kiselev E, Tropea JE, Needle D, Pommier Y, Burke TR, Waugh DS.

Nucleic Acids Res. 2019 Jun 14. pii: gkz515. doi: 10.1093/nar/gkz515. [Epub ahead of print]


The molecular mechanism of dsRNA processing by a bacterial Dicer.

Jin L, Song H, Tropea JE, Needle D, Waugh DS, Gu S, Ji X.

Nucleic Acids Res. 2019 May 21;47(9):4707-4720. doi: 10.1093/nar/gkz208.


Targeting Protein-Protein Interactions of Tyrosine Phosphatases with Microarrayed Fragment Libraries Displayed on Phosphopeptide Substrate Scaffolds.

Hogan M, Bahta M, Tsuji K, Nguyen TX, Cherry S, Lountos GT, Tropea JE, Zhao BM, Zhao XZ, Waugh DS, Burke TR Jr, Ulrich RG.

ACS Comb Sci. 2019 Mar 11;21(3):158-170. doi: 10.1021/acscombsci.8b00122. Epub 2019 Jan 31.


Crystal structure of the human dual specificity phosphatase 1 catalytic domain.

Gumpena R, Lountos GT, Raran-Kurussi S, Tropea JE, Cherry S, Waugh DS.

Protein Sci. 2018 Feb;27(2):561-567. doi: 10.1002/pro.3328. Epub 2017 Nov 21.


A Small-Molecule Microarray Approach for the Identification of E2 Enzyme Inhibitors in Ubiquitin-Like Conjugation Pathways.

Zlotkowski K, Hewitt WM, Sinniah RS, Tropea JE, Needle D, Lountos GT, Barchi JJ Jr, Waugh DS, Schneekloth JS Jr.

SLAS Discov. 2017 Jul;22(6):760-766. doi: 10.1177/2472555216683937. Epub 2017 Jan 6.


Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9.

Hewitt WM, Lountos GT, Zlotkowski K, Dahlhauser SD, Saunders LB, Needle D, Tropea JE, Zhan C, Wei G, Ma B, Nussinov R, Waugh DS, Schneekloth JS Jr.

Angew Chem Int Ed Engl. 2016 May 4;55(19):5703-7. doi: 10.1002/anie.201511351. Epub 2016 Apr 1.


Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases.

Zhao BM, Keasey SL, Tropea JE, Lountos GT, Dyas BK, Cherry S, Raran-Kurussi S, Waugh DS, Ulrich RG.

PLoS One. 2015 Aug 24;10(8):e0134984. doi: 10.1371/journal.pone.0134984. eCollection 2015.


Structure of human dual-specificity phosphatase 7, a potential cancer drug target.

Lountos GT, Austin BP, Tropea JE, Waugh DS.

Acta Crystallogr F Struct Biol Commun. 2015 Jun;71(Pt 6):650-6. doi: 10.1107/S2053230X1500504X. Epub 2015 May 20.


Characterization of the p300 Taz2-p53 TAD2 complex and comparison with the p300 Taz2-p53 TAD1 complex.

Miller Jenkins LM, Feng H, Durell SR, Tagad HD, Mazur SJ, Tropea JE, Bai Y, Appella E.

Biochemistry. 2015 Mar 24;54(11):2001-10. doi: 10.1021/acs.biochem.5b00044. Epub 2015 Mar 16.


Structural analysis of human dual-specificity phosphatase 22 complexed with a phosphotyrosine-like substrate.

Lountos GT, Cherry S, Tropea JE, Waugh DS.

Acta Crystallogr F Struct Biol Commun. 2015 Feb;71(Pt 2):199-205. doi: 10.1107/S2053230X15000217. Epub 2015 Jan 28.


Structural insights into interactions of C/EBP transcriptional activators with the Taz2 domain of p300.

Bhaumik P, Davis J, Tropea JE, Cherry S, Johnson PF, Miller M.

Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1914-21. doi: 10.1107/S1399004714009262. Epub 2014 Jun 29.


Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis.

Shaw GX, Li Y, Shi G, Wu Y, Cherry S, Needle D, Zhang D, Tropea JE, Waugh DS, Yan H, Ji X.

FEBS J. 2014 Sep;281(18):4123-37. doi: 10.1111/febs.12896. Epub 2014 Jul 23.


RNase III: Genetics and function; structure and mechanism.

Court DL, Gan J, Liang YH, Shaw GX, Tropea JE, Costantino N, Waugh DS, Ji X.

Annu Rev Genet. 2013;47:405-31. doi: 10.1146/annurev-genet-110711-155618. Review.


Differential temperature dependence of tobacco etch virus and rhinovirus 3C proteases.

Raran-Kurussi S, Tözsér J, Cherry S, Tropea JE, Waugh DS.

Anal Biochem. 2013 May 15;436(2):142-4. doi: 10.1016/j.ab.2013.01.031. Epub 2013 Feb 7.


Biomolecular Interactions of small-molecule inhibitors affecting the YopH protein tyrosine phosphatase.

Hogan M, Bahta M, Cherry S, Lountos GT, Tropea JE, Zhao BM, Burke TR Jr, Waugh DS, Ulrich RG.

Chem Biol Drug Des. 2013 Mar;81(3):323-33. doi: 10.1111/cbdd.12097.


Structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas' disease.

Lountos GT, Tropea JE, Waugh DS.

Mol Biochem Parasitol. 2013 Jan;187(1):1-8. doi: 10.1016/j.molbiopara.2012.10.006. Epub 2012 Nov 5.


Structure of the cytoplasmic domain of Yersinia pestis YscD, an essential component of the type III secretion system.

Lountos GT, Tropea JE, Waugh DS.

Acta Crystallogr D Biol Crystallogr. 2012 Mar;68(Pt 3):201-9. doi: 10.1107/S0907444911054308. Epub 2012 Feb 7.


Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy.

Lountos GT, Jobson AG, Tropea JE, Self CR, Zhang G, Pommier Y, Shoemaker RH, Waugh DS.

J Struct Biol. 2011 Dec;176(3):292-301. doi: 10.1016/j.jsb.2011.09.008. Epub 2011 Sep 22.


X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket.

Lountos GT, Jobson AG, Tropea JE, Self CR, Zhang G, Pommier Y, Shoemaker RH, Waugh DS.

FEBS Lett. 2011 Oct 20;585(20):3245-9. doi: 10.1016/j.febslet.2011.08.050. Epub 2011 Sep 7.


The Era GTPase recognizes the GAUCACCUCC sequence and binds helix 45 near the 3' end of 16S rRNA.

Tu C, Zhou X, Tarasov SG, Tropea JE, Austin BP, Waugh DS, Court DL, Ji X.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10156-61. doi: 10.1073/pnas.1017679108. Epub 2011 Jun 6.

Supplemental Content

Loading ...
Support Center