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Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus.
Gomez-Bañuelos E, Yu Y, Li J, Cashman KS, Paz M, Trejo-Zambrano MI, Bugrovsky R, Wang Y, Chida AS, Sherman-Baust CA, Ferris DP, Goldman DW, Darrah E, Petri M, Sanz I, Andrade F. Gomez-Bañuelos E, et al. Among authors: trejo zambrano mi. Nat Commun. 2023 Mar 20;14(1):1388. doi: 10.1038/s41467-023-37083-x. Nat Commun. 2023. PMID: 36941260 Free PMC article.
IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function.
Casciola-Rosen L, Thiemann DR, Andrade F, Trejo-Zambrano MI, Leonard EK, Spangler JB, Skinner NE, Bailey J, Yegnasubramanian S, Wang R, Vaghasia AM, Gupta A, Cox AL, Ray SC, Linville RM, Guo Z, Searson PC, Machamer CE, Desiderio S, Sauer LM, Laeyendecker O, Garibaldi BT, Gao L, Damarla M, Hassoun PM, Hooper JE, Mecoli CA, Christopher-Stine L, Gutierrez-Alamillo L, Yang Q, Hines D, Clarke WA, Rothman RE, Pekosz A, Fenstermacher KZ, Wang Z, Zeger SL, Rosen A. Casciola-Rosen L, et al. Among authors: trejo zambrano mi. JCI Insight. 2022 May 9;7(9):e158362. doi: 10.1172/jci.insight.158362. JCI Insight. 2022. PMID: 35349483 Free PMC article.
IgM autoantibodies recognizing ACE2 are associated with severe COVID-19.
Casciola-Rosen L, Thiemann DR, Andrade F, Trejo Zambrano MI, Hooper JE, Leonard EK, Spangler JB, Cox AL, Machamer CE, Sauer L, Laeyendecker O, Garibaldi BT, Ray SC, Mecoli CA, Christopher-Stine L, Gutierrez-Alamillo L, Yang Q, Hines D, Clarke WA, Rothman R, Pekosz A, Fenstermacher KJ, Wang Z, Zeger SL, Rosen A. Casciola-Rosen L, et al. Among authors: trejo zambrano mi. medRxiv [Preprint]. 2020 Oct 15:2020.10.13.20211664. doi: 10.1101/2020.10.13.20211664. medRxiv. 2020. PMID: 33083808 Free PMC article. Updated. Preprint.
PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases.
Madera-Salcedo IK, Sánchez-Hernández BE, Svyryd Y, Esquivel-Velázquez M, Rodríguez-Rodríguez N, Trejo-Zambrano MI, García-González HB, Hernández-Molina G, Mutchinick OM, Alcocer-Varela J, Rosetti F, Crispín JC. Madera-Salcedo IK, et al. Among authors: trejo zambrano mi. JCI Insight. 2019 Jul 23;5(16):e126457. doi: 10.1172/jci.insight.126457. JCI Insight. 2019. PMID: 31335320 Free PMC article.
Differential Treatments Based on Drug-induced Gene Expression Signatures and Longitudinal Systemic Lupus Erythematosus Stratification.
Toro-Domínguez D, Lopez-Domínguez R, García Moreno A, Villatoro-García JA, Martorell-Marugán J, Goldman D, Petri M, Wojdyla D, Pons-Estel BA, Isenberg D, Morales-Montes de Oca G, Trejo-Zambrano MI, García González B, Rosetti F, Gómez-Martín D, Romero-Díaz J, Carmona-Sáez P, Alarcón-Riquelme ME. Toro-Domínguez D, et al. Among authors: trejo zambrano mi. Sci Rep. 2019 Oct 29;9(1):15502. doi: 10.1038/s41598-019-51616-9. Sci Rep. 2019. PMID: 31664045 Free PMC article.