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Items: 17

1.

Computational prediction of GPCR oligomerization.

Townsend-Nicholson A, Altwaijry N, Potterton A, Morao I, Heifetz A.

Curr Opin Struct Biol. 2019 Apr;55:178-184. doi: 10.1016/j.sbi.2019.04.005. Epub 2019 Jun 4. Review.

PMID:
31170578
2.

Characterising GPCR-ligand interactions using a fragment molecular orbital-based approach.

Heifetz A, James T, Southey M, Morao I, Aldeghi M, Sarrat L, Fedorov DG, Bodkin MJ, Townsend-Nicholson A.

Curr Opin Struct Biol. 2019 Apr;55:85-92. doi: 10.1016/j.sbi.2019.03.021. Epub 2019 Apr 22. Review.

PMID:
31022570
3.

Ensemble-Based Steered Molecular Dynamics Predicts Relative Residence Time of A2A Receptor Binders.

Potterton A, Husseini FS, Southey MWY, Bodkin MJ, Heifetz A, Coveney PV, Townsend-Nicholson A.

J Chem Theory Comput. 2019 May 14;15(5):3316-3330. doi: 10.1021/acs.jctc.8b01270. Epub 2019 Apr 26.

PMID:
30893556
4.

Computational Methods Used in Hit-to-Lead and Lead Optimization Stages of Structure-Based Drug Discovery.

Heifetz A, Southey M, Morao I, Townsend-Nicholson A, Bodkin MJ.

Methods Mol Biol. 2018;1705:375-394. doi: 10.1007/978-1-4939-7465-8_19.

PMID:
29188574
5.

Synergistic Use of GPCR Modeling and SDM Experiments to Understand Ligand Binding.

Potterton A, Heifetz A, Townsend-Nicholson A.

Methods Mol Biol. 2018;1705:335-343. doi: 10.1007/978-1-4939-7465-8_15.

PMID:
29188570
6.

The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle.

Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R, Mifsud B, Munroe PB, Xiao Q, Townsend-Nicholson A, Hobbs AJ, Ye S, Caulfield MJ.

Hum Mol Genet. 2018 Jan 1;27(1):199-210. doi: 10.1093/hmg/ddx375.

7.

Rapid and accurate assessment of GPCR-ligand interactions Using the fragment molecular orbital-based density-functional tight-binding method.

Morao I, Fedorov DG, Robinson R, Southey M, Townsend-Nicholson A, Bodkin MJ, Heifetz A.

J Comput Chem. 2017 Sep 5;38(23):1987-1990. doi: 10.1002/jcc.24850. Epub 2017 Jul 4.

8.

An Ensemble-Based Protocol for the Computational Prediction of Helix-Helix Interactions in G Protein-Coupled Receptors using Coarse-Grained Molecular Dynamics.

Altwaijry NA, Baron M, Wright DW, Coveney PV, Townsend-Nicholson A.

J Chem Theory Comput. 2017 May 9;13(5):2254-2270. doi: 10.1021/acs.jctc.6b01246. Epub 2017 Apr 25.

9.

An Immunological Approach to Increase the Brain's Resilience to Insults.

Lin EJ, Symes CW, Townsend-Nicholson A, Klugmann M, Klugmann CB, Lehnert K, Fong D, Young D, During MJ.

ISRN Neurosci. 2014 Apr 24;2014:103213. doi: 10.1155/2014/103213. eCollection 2014.

10.

Molecular characterisation of post-bio-electrosprayed human brain astrocytoma cells.

Eddaoudi A, Townsend-Nicholson A, Timms JF, Schorge S, Jayasinghe SN.

Analyst. 2010 Oct;135(10):2600-12. doi: 10.1039/c0an00213e. Epub 2010 Aug 6.

PMID:
20694206
11.

Involvement of P2Y1 and P2Y11 purinoceptors in parasympathetic inhibition of colonic smooth muscle.

King BF, Townsend-Nicholson A.

J Pharmacol Exp Ther. 2008 Mar;324(3):1055-63. Epub 2007 Nov 29.

PMID:
18048695
12.

A novel nucleotide receptor in Xenopus activates the cAMP second messenger pathway.

Devader C, Drew CM, Geach TJ, Tabler J, Townsend-Nicholson A, Dale L.

FEBS Lett. 2007 Nov 13;581(27):5332-6. Epub 2007 Oct 23.

13.
14.

Bio-electrosprays: the next generation of electrified jets.

Jayasinghe SN, Townsend-Nicholson A.

Biotechnol J. 2006 Sep;1(9):1018-22.

PMID:
16941448
15.

Antagonism of ATP responses at P2X receptor subtypes by the pH indicator dye, Phenol red.

King BF, Liu M, Townsend-Nicholson A, Pfister J, Padilla F, Ford AP, Gever JR, Oglesby IB, Schorge S, Burnstock G.

Br J Pharmacol. 2005 Jun;145(3):313-22.

16.

Chicken DT40 cells stably transfected with the rat P2X7 receptor ion channel: a system suitable for the study of purine receptor-mediated cell death.

Hillman KA, Harada H, Chan CM, Townsend-Nicholson A, Moss SE, Miyamoto K, Suketa Y, Burnstock G, Unwin RJ, Dunn PM.

Biochem Pharmacol. 2003 Aug 1;66(3):415-24.

PMID:
12907240
17.

Heteromultimeric P2X(1/2) receptors show a novel sensitivity to extracellular pH.

Brown SG, Townsend-Nicholson A, Jacobson KA, Burnstock G, King BF.

J Pharmacol Exp Ther. 2002 Feb;300(2):673-80.

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