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1996 1
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2012 3
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Page 1
CircTmeff1 Promotes Muscle Atrophy by Interacting with TDP-43 and Encoding A Novel TMEFF1-339aa Protein.
Chen R, Yang T, Jin B, Xu W, Yan Y, Wood N, Lehmann HI, Wang S, Zhu X, Yuan W, Chen H, Liu Z, Li G, Bowen TS, Li J, Xiao J. Chen R, et al. Adv Sci (Weinh). 2023 Jun;10(17):e2206732. doi: 10.1002/advs.202206732. Epub 2023 Apr 23. Adv Sci (Weinh). 2023. PMID: 37088818 Free PMC article.
Mechanistically, circTmeff1 directly interacts with TAR DNA-binding protein 43 (TDP-43) and promotes aggregation of TDP-43 in mitochondria, which triggers the release of mitochondrial DNA (mtDNA) into cytosol and activation of the cyclic GMP-AMP synthase (cGAS)/ stimulator of int …
Mechanistically, circTmeff1 directly interacts with TAR DNA-binding protein 43 (TDP-43) and promotes aggregation of TDP-43 in mitochondria, …
TMEFF1 and brain tumors.
Gery S, Yin D, Xie D, Black KL, Koeffler HP. Gery S, et al. Oncogene. 2003 May 8;22(18):2723-7. doi: 10.1038/sj.onc.1206351. Oncogene. 2003. PMID: 12743596
These structural domains suggest a role for TMEFF1 in growth factor signaling. TMEFF1 fused to enhanced green fluorescent protein revealed that TMEFF1 is expressed on the cell membrane. ...These data suggest that TMEFF1 may behave as a tumor suppressor …
These structural domains suggest a role for TMEFF1 in growth factor signaling. TMEFF1 fused to enhanced green fluorescent prot …
TMEFF1 overexpression and its mechanism for tumor promotion in ovarian cancer.
Nie X, Liu C, Guo Q, Zheng MJ, Gao LL, Li X, Liu DW, Zhu LC, Liu JJ, Lin B. Nie X, et al. Cancer Manag Res. 2019 Jan 17;11:839-855. doi: 10.2147/CMAR.S186080. eCollection 2019. Cancer Manag Res. 2019. PMID: 30697076 Free PMC article.
The transcription factor, p53, bound the promoter region of the TMEFF1 gene according to ChIP. CONCLUSION: TMEFF1 is a carcinogenic gene in ovarian cancer and can be regulated by p53 transcription. Through MAPK and PI3K/AKT signaling pathways, TMEFF1 promotes …
The transcription factor, p53, bound the promoter region of the TMEFF1 gene according to ChIP. CONCLUSION: TMEFF1 is a carcino …
Interaction between TMEFF1 and AHNAK proteins in ovarian cancer cells: Implications for clinical prognosis.
Nie X, Zheng M, Gao L, Hu Y, Zhuang Y, Li X, Zhu L, Liu J, Lin B. Nie X, et al. Int Immunopharmacol. 2022 Jun;107:108726. doi: 10.1016/j.intimp.2022.108726. Epub 2022 Mar 23. Int Immunopharmacol. 2022. PMID: 35338959
Furthermore, the expression of TMEFF1 and AHNAK was significantly positively correlated. The results also showed that AHNAK and TMEFF1 co-localized and interacted with each other in ovarian cancer tissues and cells. ...Therefore, the interaction between AHNAK and …
Furthermore, the expression of TMEFF1 and AHNAK was significantly positively correlated. The results also showed that AHNAK and TM …
Overexpression of TMEFF1 in Endometrial Carcinoma and the Mechanism Underlying its Promotion of Malignant Behavior in Cancer Cells.
Nie X, Gao L, Zheng M, Wang C, Wang S, Li X, Qi Y, Zhu L, Liu J, Lin B. Nie X, et al. J Cancer. 2021 Jul 31;12(19):5772-5788. doi: 10.7150/jca.58524. eCollection 2021. J Cancer. 2021. PMID: 34475991 Free PMC article.
An endometrial carcinoma cell line with low expression of TMEFF1 was constructed. Scratch and Transwell assays were used to determine the effect of TMEFF1 on cell invasion and migration. ...We also identified kinases, microRNAs and a transcription factor network rel …
An endometrial carcinoma cell line with low expression of TMEFF1 was constructed. Scratch and Transwell assays were used to determine …
MIR503HG impeded ovarian cancer progression by interacting with SPI1 and preventing TMEFF1 transcription.
Tian J, Yang L, Wang Z, Yan H. Tian J, et al. Aging (Albany NY). 2022 Jun 28;14(13):5390-5405. doi: 10.18632/aging.204147. Epub 2022 Jun 28. Aging (Albany NY). 2022. PMID: 35771155 Free PMC article.
RNA immunoprecipitation and RNA pull-down assays confirmed that MIR503HG could bind to transcription factor SPI1 (Spi-1 proto-oncogene), and dual luciferase reporter gene and Chromatin immunoprecipitation assays verified that SPI1 could bind to TMEFF1 (Transmembrane protei …
RNA immunoprecipitation and RNA pull-down assays confirmed that MIR503HG could bind to transcription factor SPI1 (Spi-1 proto-oncogene), and …
ST14 interacts with TMEFF1 and is a predictor of poor prognosis in ovarian cancer.
Nie X, Gao L, Zheng M, Wang S, Wang C, Li X, Liu O, Gou R, Liu J, Lin B. Nie X, et al. BMC Cancer. 2024 Mar 11;24(1):330. doi: 10.1186/s12885-024-11958-8. BMC Cancer. 2024. PMID: 38468232 Free PMC article.
TMEFF1 is a new protein involved in the physiological functions of the central nervous system, and we previously reported TMEFF1 can promote ovarian cancer. ...ST14 and TMEFF1 co-localize and interact with each other in ovarian cancer. ...
TMEFF1 is a new protein involved in the physiological functions of the central nervous system, and we previously reported TMEFF1 …
Roles of miR-592-3p and Its Target Gene, TMEFF1, in the Nucleus Accumbens During Incubation of Morphine Craving.
Xie B, Zhang J, Ma C, Yu H, Ni Z, Cong B, Wen D. Xie B, et al. Int J Neuropsychopharmacol. 2022 May 27;25(5):412-424. doi: 10.1093/ijnp/pyac004. Int J Neuropsychopharmacol. 2022. PMID: 35020881 Free PMC article.
RESULTS: The miR-592-3p observed to be downregulated in the NAc core was linked to the incubation of morphine craving, and a dual-luciferase assay was performed to confirm the binding sites of miR-592-3p in its target gene, tomoregulin-1 (TMEFF1). Also, gain- and loss-of-f …
RESULTS: The miR-592-3p observed to be downregulated in the NAc core was linked to the incubation of morphine craving, and a dual-luciferase …
Tomoregulin-1 (TMEFF1) inhibits nodal signaling through direct binding to the nodal coreceptor Cripto.
Harms PW, Chang C. Harms PW, et al. Genes Dev. 2003 Nov 1;17(21):2624-9. doi: 10.1101/gad.1127703. Epub 2003 Oct 16. Genes Dev. 2003. PMID: 14563676 Free PMC article.
Here we report that TMEFF1 binds to the nodal coreceptor Cripto, but does not associate with either nodal or the type I ALK (activin receptor-like kinase) 4 receptor in coimmunoprecipitation assays. The inhibition of the nodal signaling by TMEFF1 in Xenopus ectoderm …
Here we report that TMEFF1 binds to the nodal coreceptor Cripto, but does not associate with either nodal or the type I ALK (activin …
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-beta/Smad2/3 pathway.
Su Q, Wang JJ, Ren JY, Wu Q, Chen K, Tu KH, Zhang Y, Leong SW, Sarwar A, Han X, Zhang M, Dai WF, Zhang YM. Su Q, et al. Acta Pharmacol Sin. 2024 Mar 22. doi: 10.1038/s41401-024-01254-3. Online ahead of print. Acta Pharmacol Sin. 2024. PMID: 38519646
Parkin deficiency leads to upregulation of TMEFF1 which promotes migration and metastasis. TMEFF1 transcription is activated by Parkin-induced endogenous TGF-beta production and subsequent phosphorylation of Smad2/3 and its binding to TMEFF1 promotor. TGF-bet …
Parkin deficiency leads to upregulation of TMEFF1 which promotes migration and metastasis. TMEFF1 transcription is activated b …
41 results