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Clin Microbiol Infect. 2014 Dec;20(12):O1117-20. doi: 10.1111/1469-0691.12714. Epub 2014 Dec 12.

Tigecycline therapy for carbapenem-resistant Klebsiella pneumoniae (CRKP) bacteriuria leads to tigecycline resistance.

Author information

1
Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC, USA.

Abstract

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing global threat. Here, we describe the prevalence and impact of tigecycline use in a cohort of patients with CRKP bacteriuria nested within a multicentre, prospective study. In the 21-month study period, 260 unique patients were included. Tigecycline was given to 80 (31%) patients. The use of tigecycline during the index hospitalization was significantly associated with the subsequent development of tigecycline resistance in the same patient (OR, 6.13; 95% CI, 1.15-48.65; p 0.03). In conclusion, the use of tigecycline with CRKP bacteriuria is common, and is associated with the subsequent development of tigecycline resistance.

KEYWORDS:

Carbapenem-resistant Enterobacteriaceae; multidrug resistance; urinary tract infection

PMID:
24931918
PMCID:
PMC4265572
DOI:
10.1111/1469-0691.12714
[Indexed for MEDLINE]
Free PMC Article

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