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Oncoimmunology. 2013 May 1;2(5):e24077.

Thwarting galectin-induced immunosuppression in breast cancer.

Author information

1
Laboratorio de Inmunopatología; Instituto de Biología y Medicina Experimental (IBYME-CONICET); Buenos Aires, Argentina.

Abstract

Novel therapeutic strategies are needed to counteract breast cancer-associated immunosuppression. Silencing the expression of galectin-1 in a breast carcinoma model inhibited tumor growth and prevented lung metastasis by reducing the frequency and immunosuppressive activity of CD4+CD25+ FOXP3+ regulatory T cells.

KEYWORDS:

Galectin-1; breast cancer; immune escape; metastasis; regulatory T cell

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