Cardiovascular toxicity from the perspective of oxidative stress, electron transfer, and prevention by antioxidants

Peter Kovacic; Lisa A Thurn

doi:10.2174/1570161053586912

Cardiovascular toxicity from the perspective of oxidative stress, electron transfer, and prevention by antioxidants

Curr Vasc Pharmacol. 2005 Apr;3(2):107-17. doi: 10.2174/1570161053586912.

Authors

Peter Kovacic¹, Lisa A Thurn

Affiliation

¹ Department of Chemistry, San Diego State University, San Diego, CA 92182-1030, USA. pkovacic@sundown.sdsu.edu

PMID: 15853630
DOI: 10.2174/1570161053586912

Abstract

This review demonstrates that oxidative stress, reactive oxygen species, and electron transfer can serve as unifying mechanistic themes for large numbers of cardiovascular toxins, both endogenous and exogenous. Lipid peroxidation is a prevalent insult. Common among the various conditions are atherosclerosis and arrhythmia. The preventive effects of antioxidants are documented.

Publication types

Review

MeSH terms

Animals
Antioxidants / pharmacology*
Cardiovascular Diseases / chemically induced*
Cardiovascular Diseases / prevention & control*
Electron Transport / drug effects*
Environmental Pollutants / toxicity
Humans
Lipid Peroxidation / drug effects
Oxidative Stress / drug effects
Oxidative Stress / physiology*
Reactive Oxygen Species / metabolism
Signal Transduction / drug effects

Substances

Antioxidants
Environmental Pollutants
Reactive Oxygen Species