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Neuroimage Clin. 2015 Mar 24;8:95-103. doi: 10.1016/j.nicl.2015.03.017. eCollection 2015.

Three dysconnectivity patterns in treatment-resistant schizophrenia patients and their unaffected siblings.

Author information

1
Institute of Mental Health, The Second Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan 410011, China ; Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China.
2
Unit on Statistical Genomics, National Institute of Mental Health, NIH, Bethesda 20892, USA.
3
Institute of Mental Health, The Second Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan 410011, China.
4
Department of Psychiatry, The First Affiliated Hospital, China Medical University, Shenyang, Liaoning Province 110001, China.
5
Department of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, China.
6
Department of radiology, the first people's hospital of Kunming, Kunming, Yunnan province, China, 650011.
7
State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410078, China.
8
Genetic Epidemiology Research Branch, Intramural Research Program, National Institute of Mental Health, Bethesda, MD 20892, USA.
9
Mind Research Network, Albuquerque, NM 87131, USA ; Department of Electrical and Computer Engineering at the University of New Mexico, Albuquerque, NM 87106, USA.
10
Institute of Mental Health, The Second Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan 410011, China ; Unit on Statistical Genomics, National Institute of Mental Health, NIH, Bethesda 20892, USA.
11
Institute of Mental Health, The Second Xiangya Hospital of Central South University, 139 Renmin Road, Changsha, Hunan 410011, China ; State Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan 410078, China ; National Technology of Institute of Psychiatry, Central South University, Changsha, Hunan 410011, China.

Abstract

Among individuals diagnosed with schizophrenia, approximately 20%-33% are recognized as treatment-resistant schizophrenia (TRS) patients. These TRS patients suffer more severely from the disease but struggle to benefit from existing antipsychotic treatments. A few recent studies suggested that schizophrenia may be caused by impaired synaptic plasticity that manifests as functional dysconnectivity in the brain, however, few of those studies focused on the functional connectivity changes in the brains of TRS groups. In this study, we compared the whole brain connectivity variations in TRS patients, their unaffected siblings, and healthy controls. Connectivity network features between and within the 116 automated anatomical labeling (AAL) brain regions were calculated and compared using maps created with three contrasts: patient vs. control, patient vs. sibling, and sibling vs.

CONTROL:

To evaluate the predictive power of the selected features, we performed a multivariate classification approach. We also evaluated the influence of six important clinical measures (e.g. age, education level) on the connectivity features. This study identified abnormal significant connectivity changes of three patterns in TRS patients and their unaffected siblings: 1) 69 patient-specific connectivity (PCN); 2) 102 shared connectivity (SCN); and 3) 457 unshared connectivity (UCN). While the first two patterns were widely reported by previous non-TRS specific studies, we were among the first to report widespread significant connectivity differences between TRS patient groups and their healthy sibling groups. Observations of this study may provide new insights for the understanding of the neurophysiological mechanisms of TRS.

KEYWORDS:

Brain plasticity; Functional connectivity; Schizophrenia; Sibling controls; TRS

PMID:
26106532
PMCID:
PMC4473730
DOI:
10.1016/j.nicl.2015.03.017
[Indexed for MEDLINE]
Free PMC Article

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