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ADAMDEC1 Maintains a Growth Factor Signaling Loop in Cancer Stem Cells.

Jimenez-Pascual A, Hale JS, Kordowski A, Pugh J, Silver DJ, Bayik D, Roversi G, Alban TJ, Rao S, Chen R, McIntyre TM, Colombo G, Taraboletti G, Holmberg KO, Forsberg-Nilsson K, Lathia JD, Siebzehnrubl FA.

Cancer Discov. 2019 Nov;9(11):1574-1589. doi: 10.1158/2159-8290.CD-18-1308. Epub 2019 Aug 21.


Acute phase protein, α - 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses.

Sumanth MS, Abhilasha KV, Jacob SP, Chaithra VH, Basrur V, Willard B, McIntyre TM, Prabhu KS, Marathe GK.

Immunobiology. 2019 Sep;224(5):672-680. doi: 10.1016/j.imbio.2019.06.003. Epub 2019 Jun 20.


CD36 Enhances Vascular Smooth Muscle Cell Proliferation and Development of Neointimal Hyperplasia.

Yue H, Febbraio M, Klenotic PA, Kennedy DJ, Wu Y, Chen S, Gohara AF, Li O, Belcher A, Kuang B, McIntyre TM, Silverstein RL, Li W.

Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):263-275. doi: 10.1161/ATVBAHA.118.312186.


Modulation of inflammatory platelet-activating factor (PAF) receptor by the acyl analogue of PAF.

Chaithra VH, Jacob SP, Lakshmikanth CL, Sumanth MS, Abhilasha KV, Chen CH, Thyagarajan A, Sahu RP, Travers JB, McIntyre TM, Kemparaju K, Marathe GK.

J Lipid Res. 2018 Nov;59(11):2063-2074. doi: 10.1194/jlr.M085704. Epub 2018 Aug 23.


D-2-Hydroxyglutarate Is an Intercellular Mediator in IDH-Mutant Gliomas Inhibiting Complement and T Cells.

Zhang L, Sorensen MD, Kristensen BW, Reifenberger G, McIntyre TM, Lin F.

Clin Cancer Res. 2018 Nov 1;24(21):5381-5391. doi: 10.1158/1078-0432.CCR-17-3855. Epub 2018 Jul 13.


The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF.

Chen R, Jin G, McIntyre TM.

J Biol Chem. 2017 Jun 16;292(24):10112-10122. doi: 10.1074/jbc.M116.771642. Epub 2017 Apr 28.


Escherichia coli Braun Lipoprotein (BLP) exhibits endotoxemia - like pathology in Swiss albino mice.

Lakshmikanth CL, Jacob SP, Kudva AK, Latchoumycandane C, Yashaswini PS, Sumanth MS, Goncalves-de-Albuquerque CF, Silva AR, Singh SA, Castro-Faria-Neto HC, Prabhu SK, McIntyre TM, Marathe GK.

Sci Rep. 2016 Oct 4;6:34666. doi: 10.1038/srep34666.


The Role of Platelet Activation and Inflammation in Early Brain Injury Following Subarachnoid Hemorrhage.

Frontera JA, Provencio JJ, Sehba FA, McIntyre TM, Nowacki AS, Gordon E, Weimer JM, Aledort L.

Neurocrit Care. 2017 Feb;26(1):48-57. doi: 10.1007/s12028-016-0292-4.


PAF is a potent pyrogen and cryogen in rodents, but it does not mediate thermoregulatory responses to bacterial endotoxin.

Marathe GK, McIntyre TM.

Temperature (Austin). 2015 Dec 3;2(4):449-50. doi: 10.1080/23328940.2015.1096439. eCollection 2015 Oct-Dec.


Lipopolysaccharide Cross-Tolerance Delays Platelet-Activating Factor-Induced Sudden Death in Swiss Albino Mice: Involvement of Cyclooxygenase in Cross-Tolerance.

Jacob SP, Lakshmikanth CL, Chaithra VH, Kumari TR, Chen CH, McIntyre TM, Marathe GK.

PLoS One. 2016 Apr 11;11(4):e0153282. doi: 10.1371/journal.pone.0153282. eCollection 2016.


Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk.

Zhu W, Gregory JC, Org E, Buffa JA, Gupta N, Wang Z, Li L, Fu X, Wu Y, Mehrabian M, Sartor RB, McIntyre TM, Silverstein RL, Tang WHW, DiDonato JA, Brown JM, Lusis AJ, Hazen SL.

Cell. 2016 Mar 24;165(1):111-124. doi: 10.1016/j.cell.2016.02.011. Epub 2016 Mar 10.


Enhanced Sphingomyelinase Activity Contributes to the Apoptotic Capacity of Electronegative Low-Density Lipoprotein.

Ke LY, Chan HC, Chen CC, Lu J, Marathe GK, Chu CS, Chan HC, Wang CY, Tung YC, McIntyre TM, Yen JH, Chen CH.

J Med Chem. 2016 Feb 11;59(3):1032-40. doi: 10.1021/acs.jmedchem.5b01534. Epub 2016 Feb 2.


Inflammatory PAF Receptor Signaling Initiates Hedgehog Signaling and Kidney Fibrogenesis During Ethanol Consumption.

Latchoumycandane C, Hanouneh M, Nagy LE, McIntyre TM.

PLoS One. 2015 Dec 31;10(12):e0145691. doi: 10.1371/journal.pone.0145691. eCollection 2015.


Deubiquitinases Modulate Platelet Proteome Ubiquitination, Aggregation, and Thrombosis.

Gupta N, Li W, McIntyre TM.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2657-66. doi: 10.1161/ATVBAHA.115.306054. Epub 2015 Oct 15.


Platelet-activating factor receptor affects food intake and body weight.

Li W, McIntyre TM.

Genes Dis. 2015 Sep;2(3):255-260. doi: 10.1016/j.gendis.2015.06.002. Epub 2015 Jun 24.


Myeloperoxidase formation of PAF receptor ligands induces PAF receptor-dependent kidney injury during ethanol consumption.

Latchoumycandane C, Nagy LE, McIntyre TM.

Free Radic Biol Med. 2015 Sep;86:179-90. doi: 10.1016/j.freeradbiomed.2015.05.020. Epub 2015 May 21.


Thymidine phosphorylase participates in platelet signaling and promotes thrombosis.

Li W, Gigante A, Perez-Perez MJ, Yue H, Hirano M, McIntyre TM, Silverstein RL.

Circ Res. 2014 Dec 5;115(12):997-1006. doi: 10.1161/CIRCRESAHA.115.304591. Epub 2014 Oct 6.


Apolipoprotein A1 regulates coenzyme Q10 absorption, mitochondrial function, and infarct size in a mouse model of myocardial infarction.

Dadabayev AR, Yin G, Latchoumycandane C, McIntyre TM, Lesnefsky EJ, Penn MS.

J Nutr. 2014 Jul;144(7):1030-6. doi: 10.3945/jn.113.184291. Epub 2014 Apr 23.


OxNASH score correlates with histologic features and severity of nonalcoholic fatty liver disease.

Alkhouri N, Berk M, Yerian L, Lopez R, Chung YM, Zhang R, McIntyre TM, Feldstein AE, Hazen SL.

Dig Dis Sci. 2014 Jul;59(7):1617-24. doi: 10.1007/s10620-014-3031-8. Epub 2014 Jan 25.

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