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Items: 1 to 20 of 46


Structural Basis of BRCC36 Function in DNA Repair and Immune Regulation.

Rabl J, Bunker RD, Schenk AD, Cavadini S, Gill ME, Abdulrahman W, Andrés-Pons A, Luijsterburg MS, Ibrahim AFM, Branigan E, Aguirre JD, Marceau AH, Guérillon C, Bouwmeester T, Hassiepen U, Peters AHFM, Renatus M, Gelman L, Rubin SM, Mailand N, van Attikum H, Hay RT, Thomä NH.

Mol Cell. 2019 Aug 8;75(3):483-497.e9. doi: 10.1016/j.molcel.2019.06.002. Epub 2019 Jun 25.


Publisher Correction: DNA damage detection in nucleosomes involves DNA register shifting.

Matsumoto S, Cavadini S, Bunker RD, Grand RS, Potenza A, Rabl J, Yamamoto J, Schenk AD, Schübeler D, Iwai S, Sugasawa K, Kurumizaka H, Thomä NH.

Nature. 2019 Jul;571(7764):E6. doi: 10.1038/s41586-019-1343-8.


Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane.

Fontana GA, Hess D, Reinert JK, Mattarocci S, Falquet B, Klein D, Shore D, Thomä NH, Rass U.

Nat Commun. 2019 Jun 10;10(1):2535. doi: 10.1038/s41467-019-10349-z.


DNA damage detection in nucleosomes involves DNA register shifting.

Matsumoto S, Cavadini S, Bunker RD, Grand RS, Potenza A, Rabl J, Yamamoto J, Schenk AD, Schübeler D, Iwai S, Sugasawa K, Kurumizaka H, Thomä NH.

Nature. 2019 Jul;571(7763):79-84. doi: 10.1038/s41586-019-1259-3. Epub 2019 May 29. Erratum in: Nature. 2019 Jun 26;:.


Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.

Sievers QL, Petzold G, Bunker RD, Renneville A, Słabicki M, Liddicoat BJ, Abdulrahman W, Mikkelsen T, Ebert BL, Thomä NH.

Science. 2018 Nov 2;362(6414). pii: eaat0572. doi: 10.1126/science.aat0572.


Regulatory control of DNA end resection by Sae2 phosphorylation.

Cannavo E, Johnson D, Andres SN, Kissling VM, Reinert JK, Garcia V, Erie DA, Hess D, Thomä NH, Enchev RI, Peter M, Williams RS, Neale MJ, Cejka P.

Nat Commun. 2018 Oct 1;9(1):4016. doi: 10.1038/s41467-018-06417-5.


Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks.

Fontana GA, Reinert JK, Thomä NH, Rass U.

Microb Cell. 2018 May 17;5(7):327-343. doi: 10.15698/mic2018.07.639. Review.


Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes.

Ostapcuk V, Mohn F, Carl SH, Basters A, Hess D, Iesmantavicius V, Lampersberger L, Flemr M, Pandey A, Thomä NH, Betschinger J, Bühler M.

Nature. 2018 May;557(7707):739-743. doi: 10.1038/s41586-018-0153-8. Epub 2018 May 23.


Rif1 maintains telomeres and mediates DNA repair by encasing DNA ends.

Mattarocci S, Reinert JK, Bunker RD, Fontana GA, Shi T, Klein D, Cavadini S, Faty M, Shyian M, Hafner L, Shore D, Thomä NH, Rass U.

Nat Struct Mol Biol. 2017 Jul;24(7):588-595. doi: 10.1038/nsmb.3420. Epub 2017 Jun 12.


Targeted protein degradation: You can glue it too!

Walczak MJ, Petzold G, Thomä NH.

Nat Chem Biol. 2017 Apr 13;13(5):452-453. doi: 10.1038/nchembio.2355. No abstract available.


Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome.

Cavadini S, Fischer ES, Bunker RD, Potenza A, Lingaraju GM, Goldie KN, Mohamed WI, Faty M, Petzold G, Beckwith RE, Tichkule RB, Hassiepen U, Abdulrahman W, Pantelic RS, Matsumoto S, Sugasawa K, Stahlberg H, Thomä NH.

Nature. 2016 Mar 31;531(7596):598-603. doi: 10.1038/nature17416.


Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase.

Petzold G, Fischer ES, Thomä NH.

Nature. 2016 Apr 7;532(7597):127-30. doi: 10.1038/nature16979. Epub 2016 Feb 24.


SPLINTS: small-molecule protein ligand interface stabilizers.

Fischer ES, Park E, Eck MJ, Thomä NH.

Curr Opin Struct Biol. 2016 Apr;37:115-22. doi: 10.1016/ Epub 2016 Jan 30. Review.


Structural basis of pyrimidine-pyrimidone (6-4) photoproduct recognition by UV-DDB in the nucleosome.

Osakabe A, Tachiwana H, Kagawa W, Horikoshi N, Matsumoto S, Hasegawa M, Matsumoto N, Toga T, Yamamoto J, Hanaoka F, Thomä NH, Sugasawa K, Iwai S, Kurumizaka H.

Sci Rep. 2015 Nov 17;5:16330. doi: 10.1038/srep16330.


Functional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein.

Matsumoto S, Fischer ES, Yasuda T, Dohmae N, Iwai S, Mori T, Nishi R, Yoshino K, Sakai W, Hanaoka F, Thomä NH, Sugasawa K.

Nucleic Acids Res. 2015 Feb 18;43(3):1700-13. doi: 10.1093/nar/gkv038. Epub 2015 Jan 27.


Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide.

Fischer ES, Böhm K, Lydeard JR, Yang H, Stadler MB, Cavadini S, Nagel J, Serluca F, Acker V, Lingaraju GM, Tichkule RB, Schebesta M, Forrester WC, Schirle M, Hassiepen U, Ottl J, Hild M, Beckwith RE, Harper JW, Jenkins JL, Thomä NH.

Nature. 2014 Aug 7;512(7512):49-53. doi: 10.1038/nature13527. Epub 2014 Jul 16.


Crystal structure of the human COP9 signalosome.

Lingaraju GM, Bunker RD, Cavadini S, Hess D, Hassiepen U, Renatus M, Fischer ES, Thomä NH.

Nature. 2014 Aug 14;512(7513):161-5. doi: 10.1038/nature13566. Epub 2014 Jul 16.


Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7.

Mattarocci S, Shyian M, Lemmens L, Damay P, Altintas DM, Shi T, Bartholomew CR, Thomä NH, Hardy CF, Shore D.

Cell Rep. 2014 Apr 10;7(1):62-9. doi: 10.1016/j.celrep.2014.03.010. Epub 2014 Mar 27.


Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIα and RMI1.

Bocquet N, Bizard AH, Abdulrahman W, Larsen NB, Faty M, Cavadini S, Bunker RD, Kowalczykowski SC, Cejka P, Hickson ID, Thomä NH.

Nat Struct Mol Biol. 2014 Mar;21(3):261-8. doi: 10.1038/nsmb.2775. Epub 2014 Feb 9.


Rif1 and Rif2 shape telomere function and architecture through multivalent Rap1 interactions.

Shi T, Bunker RD, Mattarocci S, Ribeyre C, Faty M, Gut H, Scrima A, Rass U, Rubin SM, Shore D, Thomä NH.

Cell. 2013 Jun 6;153(6):1340-53. doi: 10.1016/j.cell.2013.05.007.

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