Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Sci Transl Med. 2018 May 16;10(441). pii: eaan4886. doi: 10.1126/scitranslmed.aan4886.

The protective role of macrophage migration inhibitory factor in acute kidney injury after cardiac surgery.

Author information

1
Department of Intensive Care Medicine, University Hospital, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany. christian.stoppe@gmail.com juergen.bernhagen@med.uni-muenchen.de pboor@ukaachen.de.
2
Department of Intensive Care Medicine, University Hospital, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany.
3
Department of Thoracic, Cardiac and Vascular Surgery, University Hospital, RWTH Aachen, Aachen, Germany.
4
Department of Nephrology, Yale University School of Medicine, New Haven, CT 06510, USA.
5
Department of Anesthesiology, University Hospital, RWTH Aachen, Aachen, Germany.
6
Department of Plastic and Reconstructive Surgery, Hand Surgery, Burn Center, RWTH Aachen, Aachen, Germany.
7
Department of Anesthesiology, University Hospitals Leuven, Leuven, Belgium.
8
Department of Nephropathology, Yale University School of Medicine, New Haven, CT 06520, USA.
9
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
10
Division of Nephrology, Department of Internal Medicine III, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Dresden, Germany.
11
Department of Vascular Biology, Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University Munich, Munich, Germany.
12
Department of Anesthesiology, Critical Care Medicine and Pain Therapy, University Hospital Münster, Münster, Germany.
13
Department of Vascular Biology, Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University Munich, Munich, Germany. christian.stoppe@gmail.com juergen.bernhagen@med.uni-muenchen.de pboor@ukaachen.de.
14
German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.
15
Munich Cluster for Systems Neurology (EXC 1010 SyNergy), Munich, Germany.
16
Institute of Pathology and Department of Nephrology, University Hospital, RWTH Aachen, Aachen, Germany.
17
Institute of Pathology and Department of Nephrology, University Hospital, RWTH Aachen, Aachen, Germany. christian.stoppe@gmail.com juergen.bernhagen@med.uni-muenchen.de pboor@ukaachen.de.
18
Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia.

Abstract

Acute kidney injury (AKI) represents the most frequent complication after cardiac surgery. Macrophage migration inhibitory factor (MIF) is a stress-regulating cytokine that was shown to protect the heart from myocardial ischemia-reperfusion injury, but its role in the pathogenesis of AKI remains unknown. In an observational study, serum and urinary MIF was quantified in 60 patients scheduled for elective conventional cardiac surgery with the use of cardiopulmonary bypass. Cardiac surgery triggered an increase in MIF serum concentrations, and patients with high circulating MIF (>median) 12 hours after surgery had a significantly reduced risk of developing AKI (relative risk reduction, 72.7%; 95% confidence interval, 12 to 91.5%; P = 0.03). Experimental AKI was induced in wild-type and Mif-/- mice by 30 min of ischemia followed by 6 or 24 hours of reperfusion, or by rhabdomyolysis. Mif-deficient mice exhibited increased tubular cell injury, increased regulated cell death (necroptosis and ferroptosis), and enhanced oxidative stress. Therapeutic administration of recombinant MIF after ischemia-reperfusion in mice ameliorated AKI. In vitro treatment of tubular epithelial cells with recombinant MIF reduced cell death and oxidative stress as measured by glutathione and thiobarbituric acid reactive substances in the setting of hypoxia. Our data provide evidence of a renoprotective role of MIF in experimental ischemia-reperfusion injury by protecting renal tubular epithelial cells, consistent with our observation that high MIF in cardiac surgery patients is associated with a reduced incidence of AKI.

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center