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Oxid Med Cell Longev. 2018 Oct 3;2018:2157496. doi: 10.1155/2018/2157496. eCollection 2018.

The Effect of Whole-Body Cryotherapy at Different Temperatures on Proinflammatory Cytokines, Oxidative Stress Parameters, and Disease Activity in Patients with Ankylosing Spondylitis.

Author information

1
Chair of Physical Therapy and Sports Recovery, Poznan University of Physical Education, Droga Dębińska 10C, 61-555 Poznań, Poland.
2
Department of General Chemistry, Chair of Chemistry and Clinical Biochemistry, Poznan University of Medical Sciences, Rokietnicka 9, 60-806 Poznań, Poland.
3
Department of Rheumatology and Rehabilitation, Poznan University of Medical Sciences, 28 Czerwca 1956 135/147, 61-545 Poznań, Poland.
4
Rheumatological Centre in Śrem, Mickiewicza 95, 63-100 Śrem, Poland.

Abstract

Purpose:

Patients with ankylosing spondylitis (AS) have increased production of proinflammatory cytokines, increased oxidants, and decreased antioxidant capacity. The aim of this study was to determine the effect of whole-body cryotherapy (WBC) at -110°C and -60°C, on disease activity, selected proinflammatory cytokines, and oxidative stress in patients with AS.

Methods:

Sixty-five patients with AS were recruited to one of three study procedures: WBC at -110°C, -60°C, or exercise therapy (non-WBC). The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP), concentration of C-reactive protein (CRP), and the concentrations of interleukin 8 and 17 (IL-8, IL-17) were measured at the beginning of the study and at the end of the intervention. The concentration of thiobarbituric acid reactive substances (TBARS), as a lipid peroxidation result, and total antioxidant status, an antioxidant organism potential, were measured.

Results:

All the studied groups showed significantly decreased posttherapy disease activity expressed as a function of the BASDAI, ASDAS-CRP, and the IL-8 concentration. We found that the TBARS concentration after therapy was significantly increased in the WBC at -110°C group. A comparison of the therapeutic effects between the treatment groups showed a significantly lower BASDAI after therapy in the WBC at -110°C group compared to the non-WBC group.

Conclusion:

WBC at -110°C had a positive effect on lowering AS clinical activity as measured by the BASDAI.

PMID:
30402204
PMCID:
PMC6192087
DOI:
10.1155/2018/2157496
[Indexed for MEDLINE]
Free PMC Article

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