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Antimicrob Agents Chemother. 2015 Aug;59(8):5014-7. doi: 10.1128/AAC.00533-15. Epub 2015 May 18.

Effect of Resistance Mechanisms on the Inoculum Effect of Carbapenem in Klebsiella pneumoniae Isolates with Borderline Carbapenem Resistance.

Author information

1
National Center for Infection Control, Ministry of Health, Tel Aviv, Israel; Section of Epidemiology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel amosa@tlvmc.gov.il.
2
National Center for Infection Control, Ministry of Health, Tel Aviv, Israel; Section of Epidemiology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel.

Abstract

We aimed to examine the effects of resistance mechanisms on several resistance phenotypes among carbapenem-resistant Klebsiella pneumoniae isolates with borderline carbapenem MICs. We compared carbapenemase-negative K. pneumoniae with carbapenemase-producing K. pneumoniae (CPKP) isolates with similar MICs. CPKP isolates exhibited a marked inoculum effect and were more resistant to the bactericidal effect of meropenem. This suggests that MIC measurements alone may not be sufficient in predicting the therapeutic efficacy of carbapenems against CPKP.

PMID:
25987630
PMCID:
PMC4505287
DOI:
10.1128/AAC.00533-15
[Indexed for MEDLINE]
Free PMC Article

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