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Crit Rev Oncol Hematol. 2018 Oct;130:1-12. doi: 10.1016/j.critrevonc.2018.06.007. Epub 2018 Jun 18.

The changing scenario of 1st line therapy in non-oncogene addicted NSCLCs in the era of immunotherapy.

Author information

1
Medical Oncology Unit A.O. Papardo & Department of Human Pathology, University of Messina, Italy.
2
Medical Oncology Unit A.O. Papardo & Department of Human Pathology, University of Messina, Italy. Electronic address: vadamo@unime.it.

Abstract

During the last two decades front-line treatment of metastatic Non Small Cell Lung Cancer (NSCLC) has profoundly changed moving from the old "one size fits all" concept to a "histology-based" approach and then, for a small subgroup of patients to a "molecularly-selected" one. The development of immune checkpoint inhibitors and the unprecedented results reported in 2nd/3rd line prompted the evaluation of these novel therapeutic agents in chemotherapy-naïve patients either alone or in combination with platinum-based chemotherapy. Several randomized trials are evaluating the impact of immune-checkpoint inhibitors in 1st line and some of them have yet produced preliminary evidence of efficacy. However, still a long way to go and several questions are still unanswered, including proper patients selection, optimal sequential/combinatorial use of these agents, appropriate treatment duration, and finally the identification of predictive biomarkers. The aim of this paper is to provide a comprehensive overview on the growing role of immune checkpoint inhibitors in the upfront treatment of advanced non-oncogene addicted NSCLC either as single agent or in combination with other agents.

KEYWORDS:

Atezolizumab; Avelumab; Durvalumab; First line; Immunotherapy; NSCLC; Nivolumab; Pembrolizumab

[Indexed for MEDLINE]

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