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J Diabetes Res. 2016;2016:2931985. doi: 10.1155/2016/2931985. Epub 2016 Mar 30.

The Burden of NAFLD and Its Characteristics in a Nationwide Population with Type 2 Diabetes.

Author information

1
Unit of Metabolic Diseases and Clinical Dietetics, "Alma Mater Studiorum" University of Bologna, 40138 Bologna, Italy.
2
Diabetes and Metabolism Unit, ASL Turin 5, 10023 Chieri, Italy.
3
Unit of Internal Medicine, IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.
4
Center for Outcomes Research and Clinical Epidemiology (CORE), 65124 Pescara, Italy.
5
Diabetes Unit, AUSL Romagna, 48121 Ravenna, Italy.
6
Biomedical Research Institute August Pi Sunyer (IDIBAPS) and Center for Biomedical Research in Diabetes and Associated Metabolic Disorders (CIBERDEM), 08036 Barcelona, Spain.
7
AMD (Italian Association of Clinical Diabetologists), 00192 Rome, Italy.

Abstract

OBJECTIVE:

We studied the prevalence of nonalcoholic fatty liver disease (NAFLD) and its clinical correlates in a population of patients with type 2 diabetes mellitus (T2DM).

METHODS:

Clinical data of 94,577 T2DM patients were retrieved from 160 diabetes clinics in Italy in a standardized format and centrally analyzed anonymously. After exclusion of 5967 cases (high or uncertain alcohol intake), in 38,880 the Fatty Liver Index (FLI) was used as a proxy for the diagnosis of NAFLD. Factors associated with FLI assessed NAFLD (FLI-NAFLD) were evaluated through multivariate analysis.

RESULTS:

FLI-NAFLD was present in 59.6% of patients. Compared to non-NAFLD, FLI-NAFLD was associated with impairment in renal function, higher albumin excretion, HbA1c and blood pressure, lower HDL cholesterol, and poorer quality of care. ALT was within normal limits in 73.6% of FLI-NAFLD patients (45.6% if the updated reference values were used). The prevalence of FLI-NAFLD did not differ if the whole sample (94,577 cases) was examined, irrespective of alcohol intake.

CONCLUSIONS:

FLI-NAFLD was present in the majority of T2DM patients of our sample and metabolic derangement, not alcohol consumption, was mainly associated with the disease. FLI-NAFLD patients have a worse metabolic profile. ALT levels are not predictive of NAFLD.

PMID:
27123461
PMCID:
PMC4829721
DOI:
10.1155/2016/2931985
[Indexed for MEDLINE]
Free PMC Article

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