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J Cell Physiol. 2019 Jun;234(6):8241-8248. doi: 10.1002/jcp.27666. Epub 2018 Nov 23.

The role of HSP27 in the development of drug resistance of gastrointestinal malignancies: Current status and perspectives.

Author information

1
Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5
Division of Medical Education, Brighton & Sussex Medical School, University of Brighton, Brighton, UK.
6
Department of Medical Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Heat-shock protein 27 (HSP27) is a chaperone molecule that plays a critical role in the refolding and activity of several proteins responsible for cancer cell drug toxicity. Upregulation of HSP27 is associated with decreased drug sensitivity as well as poorer survival in gastrointestinal (GI) malignancies. It is, therefore, possible that HSP27 may be of value in the assessment of prognostic and therapeutic efficacy in the treatment of GI cancers. Pharmacological and biological inhibitors of HSP27 enhance tumor cell chemosensitivity. This review summarizes the potential role of HSP27 in chemotherapy drug resistance and the therapeutic potential of HSP27 inhibitors as a novel strategy in the treatment of GI cancers.

KEYWORDS:

drug resistance; gastrointestinal malignancies; heat-shock protein 27; survival

PMID:
30471115
DOI:
10.1002/jcp.27666

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