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Pediatr Blood Cancer. 2017 Aug;64(8). doi: 10.1002/pbc.26441. Epub 2017 Jan 18.

The McGill Interactive Pediatric OncoGenetic Guidelines: An approach to identifying pediatric oncology patients most likely to benefit from a genetic evaluation.

Author information

1
Division of Hematology/Oncology, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.
2
Division of Hematology/Oncology, Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
3
Division of Hematology/Oncology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
4
Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
5
Department of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada.
6
Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.

Abstract

Identifying cancer predisposition syndromes in children with tumors is crucial, yet few clinical guidelines exist to identify children at high risk of having germline mutations. The McGill Interactive Pediatric OncoGenetic Guidelines project aims to create a validated pediatric guideline in the form of a smartphone/tablet application using algorithms to process clinical data and help determine whether to refer a child for genetic assessment. This paper discusses the initial stages of the project, focusing on its overall structure, the methodology underpinning the algorithms, and the upcoming algorithm validation process.

KEYWORDS:

cancer genetics; cancer predisposition syndrome; familial cancer; germline mutation; pediatric

PMID:
28097779
DOI:
10.1002/pbc.26441
[Indexed for MEDLINE]

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