Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016

Euro Surveill. 2016 Jun 16;21(24). doi: 10.2807/1560-7917.ES.2016.21.24.30258.

Abstract

An influenza A(H1N1)pdm09 virus carrying a G147R substitution in combination with an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir, was detected from an immunocompromised inpatient in Japan, March 2016. This dual H275Y/G147R mutant virus exhibited enhanced cross-resistance to both drugs compared with the single H275Y mutant virus and reduced susceptibility to zanamivir, although it showed normal inhibition by laninamivir.

Keywords: A(H1N1)pdm09; influenza virus; neuraminidase inhibitor; oseltamivir-resistant influenza virus; peramivir-resistant influenza virus.

Publication types

  • Case Reports

MeSH terms

  • Acids, Carbocyclic
  • Amino Acid Substitution / genetics
  • Antiviral Agents / administration & dosage
  • Cyclopentanes / administration & dosage*
  • Drug Resistance, Viral
  • Enzyme Inhibitors / administration & dosage
  • Female
  • Guanidines / administration & dosage*
  • Humans
  • Influenza A Virus, H1N1 Subtype / drug effects*
  • Influenza A Virus, H1N1 Subtype / enzymology
  • Influenza A Virus, H1N1 Subtype / genetics*
  • Influenza, Human / drug therapy*
  • Influenza, Human / virology*
  • Japan
  • Middle Aged
  • Mutation
  • Neuraminidase / antagonists & inhibitors
  • Neuraminidase / genetics
  • Oseltamivir / administration & dosage*
  • Treatment Outcome

Substances

  • Acids, Carbocyclic
  • Antiviral Agents
  • Cyclopentanes
  • Enzyme Inhibitors
  • Guanidines
  • Oseltamivir
  • Neuraminidase
  • peramivir