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Cancer Cell. 2015 Mar 9;27(3):317-9. doi: 10.1016/j.ccell.2015.02.010.

The GLU that holds cancer together: targeting GLUtamine transporters in breast cancer.

Author information

1
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
2
Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA. Electronic address: neckersl@mail.nih.gov.

Abstract

Many cancer cells require exogenous glutamine for proliferation, supply of TCA cycle intermediates, lipid synthesis, mTOR activity, and neutralization of reactive oxygen species. In this issue of Cancer Cell, Jeon and colleagues identify chemotherapy-induced endoplasmic reticulum stress as a novel strategy to target glutamine dependence.

PMID:
25759015
DOI:
10.1016/j.ccell.2015.02.010
[Indexed for MEDLINE]
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