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J Cyst Fibros. 2016 Dec 13. pii: S1569-1993(16)30669-5. doi: 10.1016/j.jcf.2016.11.011. [Epub ahead of print]

The psychometric properties of the Leicester Cough Questionnaire and Respiratory Symptoms in CF tool in cystic fibrosis: A preliminary study.

Author information

  • 1Royal Adelaide Hospital, North Terrace, Adelaide 5000, Australia; La Trobe University, Melbourne 3004, Australia. Electronic address: nathan.ward2@sa.gov.au.
  • 2Central Adelaide Local Health Network, Adelaide 5000, Australia. Electronic address: kathy.stiller@sa.gov.au.
  • 3Royal Adelaide Hospital, North Terrace, Adelaide 5000, Australia. Electronic address: hilary.rowe@sa.gov.au.
  • 4La Trobe University, Melbourne 3004, Australia; Alfred Health, Commercial Road, Melbourne 3004, Australia. Electronic address: a.holland@latrobe.edu.au.

Abstract

BACKGROUND:

There are few tools to quantify the impact of cough in cystic fibrosis (CF). The psychometric properties of the Leicester Cough Questionnaire (LCQ) and Respiratory Symptoms in CF (ReS-CF) tool were investigated in adults with CF.

METHODS:

Validity and reliability were assessed in clinically stable participants who completed the questionnaires twice, along with the Cystic Fibrosis Questionnaire - Revised (CFQ-R). Responsiveness was assessed by change in questionnaires following treatment for an acute respiratory exacerbation.

RESULTS:

Correlations between the LCQ and CFQ-R respiratory domain were moderate (n=59, rs=0.78, p<0.001). Correlations between ReS-CF and CFQ-R respiratory domain were fair (rs=-0.50, p<0.001). The LCQ total score was repeatable (ICC 0.92, 95%CI 0.87-0.96, n=50). In those reporting improvement in symptoms following treatment (n=36), LCQ total score had a mean change of 4.6 (SD 3.7) and effect size of 1.2.

CONCLUSIONS:

The LCQ and ReS-CF appear to be valid, reliable and responsive in CF.

TRIAL REGISTRATION:

www.anzctr.org.au: ACTRN12615000262505.

KEYWORDS:

Cough; Cystic fibrosis; Leicester Cough Questionnaire; Signs and symptoms, respiratory; Surveys and questionnaires

PMID:
27986494
DOI:
10.1016/j.jcf.2016.11.011
[PubMed - as supplied by publisher]
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