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Dev Cell. 2019 May 6;49(3):325-331. doi: 10.1016/j.devcel.2019.04.002.

The Emerging Link between Centrosome Aberrations and Metastasis.

Author information

1
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
2
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: aholland@jhmi.edu.

Abstract

Centrosome aberrations are commonly observed in human tumors and correlate with tumor aggressiveness and poor prognosis. Extra centrosomes drive mitotic errors that have been implicated in promoting tumorigenesis in mice. However, centrosome aberrations can also disrupt tissue architecture and confer invasive properties that may facilitate the dissemination of metastatic cells. Recent work has shown that centrosome defects facilitate invasion through cell-autonomous and non-cell-autonomous mechanisms, suggesting cancer cells can benefit from centrosome aberrations present in a subset of the tumor cell population. Here, we discuss how centrosome defects promote invasive behaviors that may contribute to initial steps in the metastatic cascade.

KEYWORDS:

aneuploidy; cancer; centrosomes; metastasis

PMID:
31063752
PMCID:
PMC6506172
[Available on 2020-05-06]
DOI:
10.1016/j.devcel.2019.04.002
[Indexed for MEDLINE]

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