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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 1
1966 1
1967 6
1968 5
1969 3
1970 3
1971 8
1972 11
1973 14
1974 16
1975 42
1976 43
1977 44
1978 40
1979 50
1980 65
1981 92
1982 99
1983 138
1984 135
1985 143
1986 147
1987 165
1988 201
1989 215
1990 231
1991 258
1992 273
1993 241
1994 294
1995 340
1996 309
1997 372
1998 334
1999 345
2000 359
2001 367
2002 365
2003 388
2004 374
2005 354
2006 361
2007 338
2008 338
2009 336
2010 322
2011 337
2012 376
2013 393
2014 382
2015 360
2016 362
2017 308
2018 277
2019 267
2020 248
2021 281
2022 225
2023 210
2024 75

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11,993 results

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Page 1
Mechanisms of DNA replication termination.
Dewar JM, Walter JC. Dewar JM, et al. Nat Rev Mol Cell Biol. 2017 Aug;18(8):507-516. doi: 10.1038/nrm.2017.42. Epub 2017 May 24. Nat Rev Mol Cell Biol. 2017. PMID: 28537574 Free PMC article. Review.
DNA replication ends when converging replication forks meet. During this process, which is known as replication termination, DNA synthesis is completed, the replication machinery is disassembled and daughter molecules are resolved. …
DNA replication ends when converging replication forks meet. During this process, which is known as replication …
Approaches to Monitor Termination of DNA Replication Using Xenopus Egg Extracts.
Kavlashvili T, Dewar JM. Kavlashvili T, et al. Methods Mol Biol. 2022;2444:105-123. doi: 10.1007/978-1-0716-2063-2_7. Methods Mol Biol. 2022. PMID: 35290634
Despite its crucial role in genome duplication, the final stage of DNA replication, which is termed termination, is relatively unexplored. Our knowledge of termination is limited by cellular approaches to study DNA replication, which cann …
Despite its crucial role in genome duplication, the final stage of DNA replication, which is termed termination, is rel …
Genome-wide measurement of DNA replication fork directionality and quantification of DNA replication initiation and termination with Okazaki fragment sequencing.
Wu X, Liu Y, d'Aubenton-Carafa Y, Thermes C, Hyrien O, Chen CL, Petryk N. Wu X, et al. Nat Protoc. 2023 Apr;18(4):1260-1295. doi: 10.1038/s41596-022-00793-5. Epub 2023 Jan 18. Nat Protoc. 2023. PMID: 36653528 Review.
Studying the dynamics of genome replication in mammalian cells has been historically challenging. To reveal the location of replication initiation and termination in the human genome, we developed Okazaki fragment sequencing (OK-seq), a quantitative approach …
Studying the dynamics of genome replication in mammalian cells has been historically challenging. To reveal the location of replic …
Termination of DNA replication of bacterial and plasmid chromosomes.
Bussiere DE, Bastia D. Bussiere DE, et al. Mol Microbiol. 1999 Mar;31(6):1611-8. doi: 10.1046/j.1365-2958.1999.01287.x. Mol Microbiol. 1999. PMID: 10209736 Free article. Review.
Sequence-specific replication termini occur in many bacterial and plasmid chromosomes and consist of two components: a cis-acting ter site and a trans-acting replication terminator protein. The interaction of a terminator protein with the ter site crea …
Sequence-specific replication termini occur in many bacterial and plasmid chromosomes and consist of two components: a cis-acting ter …
DNA Fiber Analysis: Mind the Gap!
Quinet A, Carvajal-Maldonado D, Lemacon D, Vindigni A. Quinet A, et al. Methods Enzymol. 2017;591:55-82. doi: 10.1016/bs.mie.2017.03.019. Epub 2017 May 3. Methods Enzymol. 2017. PMID: 28645379 Review.
This approach relies on the ability of many organisms to incorporate thymidine analogs into replicating DNA and is widely used to study how genotoxic agents perturb DNA replication. Here, we review different approaches available to prepare DNA fibers a …
This approach relies on the ability of many organisms to incorporate thymidine analogs into replicating DNA and is widely used to stu …
Termination of Eukaryotic Replication Forks.
Gambus A. Gambus A. Adv Exp Med Biol. 2017;1042:163-187. doi: 10.1007/978-981-10-6955-0_8. Adv Exp Med Biol. 2017. PMID: 29357058 Review.
Termination of DNA replication forks takes place when two replication forks coming from neighbouring origins meet each other usually in the midpoint of the replicon. ...Finally, the replication machinery has to be taken off, chromatin re-assembl …
Termination of DNA replication forks takes place when two replication forks coming from neighbouring origins mee …
Regulatory R-loops as facilitators of gene expression and genome stability.
Niehrs C, Luke B. Niehrs C, et al. Nat Rev Mol Cell Biol. 2020 Mar;21(3):167-178. doi: 10.1038/s41580-019-0206-3. Epub 2020 Jan 31. Nat Rev Mol Cell Biol. 2020. PMID: 32005969 Free PMC article. Review.
R-loops are three-stranded structures that harbour an RNA-DNA hybrid and frequently form during transcription. R-loop misregulation is associated with DNA damage, transcription elongation defects, hyper-recombination and genome instability. In contrast to such 'unsc …
R-loops are three-stranded structures that harbour an RNA-DNA hybrid and frequently form during transcription. R-loop misregulation i …
The Role of Ubiquitination and SUMOylation in DNA Replication.
Abbas T. Abbas T. Curr Issues Mol Biol. 2021;40:189-220. doi: 10.21775/cimb.040.189. Epub 2020 Jul 1. Curr Issues Mol Biol. 2021. PMID: 32606249 Free article. Review.
DNA replication is a tightly regulated conserved process that ensures the faithful transmission of genetic material to define heritable phenotypic traits. Perturbations in this process result in genomic instability, mutagenesis, and diseases, including malignancy. P …
DNA replication is a tightly regulated conserved process that ensures the faithful transmission of genetic material to define …
FORK-seq: Single-Molecule Profiling of DNA Replication.
Hennion M, Theulot B, Arbona JM, Audit B, Hyrien O. Hennion M, et al. Methods Mol Biol. 2022;2477:107-128. doi: 10.1007/978-1-0716-2257-5_8. Methods Mol Biol. 2022. PMID: 35524115
Along pulse-chased replication intermediates from Saccharomyces cerevisiae, we can orient replication tracks and reproduce population-based replication directionality profiles. Additionally, we can map individual initiation and termination events. Thus …
Along pulse-chased replication intermediates from Saccharomyces cerevisiae, we can orient replication tracks and reproduce pop …
Congenital Diseases of DNA Replication: Clinical Phenotypes and Molecular Mechanisms.
Schmit M, Bielinsky AK. Schmit M, et al. Int J Mol Sci. 2021 Jan 18;22(2):911. doi: 10.3390/ijms22020911. Int J Mol Sci. 2021. PMID: 33477564 Free PMC article. Review.
Deoxyribonucleic acid (DNA) replication can be divided into three major steps: initiation, elongation and termination. ...By comparing and contrasting these diseases, we hope to illuminate how the disruption of DNA replication at distinct steps …
Deoxyribonucleic acid (DNA) replication can be divided into three major steps: initiation, elongation and termination. …
11,993 results
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