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Items: 1 to 20 of 26


Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD + depletion.

Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG.

Version 2. Wellcome Open Res. 2019 Sep 17 [revised 2019 Jan 1];3:147. doi: 10.12688/wellcomeopenres.14898.2. eCollection 2018.


Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.

Elhassan YS, Kluckova K, Fletcher RS, Schmidt MS, Garten A, Doig CL, Cartwright DM, Oakey L, Burley CV, Jenkinson N, Wilson M, Lucas SJE, Akerman I, Seabright A, Lai YC, Tennant DA, Nightingale P, Wallis GA, Manolopoulos KN, Brenner C, Philp A, Lavery GG.

Cell Rep. 2019 Aug 13;28(7):1717-1728.e6. doi: 10.1016/j.celrep.2019.07.043.


Ex vivo metabolite profiling of paediatric central nervous system tumours reveals prognostic markers.

Bennett CD, Gill SK, Kohe SE, Wilson MP, Davies NP, Arvanitis TN, Tennant DA, Peet AC.

Sci Rep. 2019 Jul 19;9(1):10473. doi: 10.1038/s41598-019-45900-x.


Development and Validation of a Combined Hypoxia and Immune Prognostic Classifier for Head and Neck Cancer.

Brooks JM, Menezes AN, Ibrahim M, Archer L, Lal N, Bagnall CJ, von Zeidler SV, Valentine HR, Spruce RJ, Batis N, Bryant JL, Hartley M, Kaul B, Ryan GB, Bao R, Khattri A, Lee SP, Ogbureke KUE, Middleton G, Tennant DA, Beggs AD, Deeks J, West CML, Cazier JB, Willcox BE, Seiwert TY, Mehanna H.

Clin Cancer Res. 2019 Sep 1;25(17):5315-5328. doi: 10.1158/1078-0432.CCR-18-3314. Epub 2019 Jun 10.


Verteporfin selectively kills hypoxic glioma cells through iron-binding and increased production of reactive oxygen species.

Eales KL, Wilkinson EA, Cruickshank G, Tucker JHR, Tennant DA.

Sci Rep. 2018 Sep 25;8(1):14358. doi: 10.1038/s41598-018-32727-1.


Tissue metabolite profiles for the characterisation of paediatric cerebellar tumours.

Bennett CD, Kohe SE, Gill SK, Davies NP, Wilson M, Storer LCD, Ritzmann T, Paine SML, Scott IS, Nicklaus-Wollenteit I, Tennant DA, Grundy RG, Peet AC.

Sci Rep. 2018 Aug 10;8(1):11992. doi: 10.1038/s41598-018-30342-8.


Oncogenic IDH1 Mutations Promote Enhanced Proline Synthesis through PYCR1 to Support the Maintenance of Mitochondrial Redox Homeostasis.

Hollinshead KER, Munford H, Eales KL, Bardella C, Li C, Escribano-Gonzalez C, Thakker A, Nonnenmacher Y, Kluckova K, Jeeves M, Murren R, Cuozzo F, Ye D, Laurenti G, Zhu W, Hiller K, Hodson DJ, Hua W, Tomlinson IP, Ludwig C, Mao Y, Tennant DA.

Cell Rep. 2018 Mar 20;22(12):3107-3114. doi: 10.1016/j.celrep.2018.02.084.


High-Speed Tracer Analysis of Metabolism (HS-TrAM).

Smith TB, Patel K, Munford H, Peet A, Tennant DA, Jeeves M, Ludwig C.

Wellcome Open Res. 2018 Jan 12;3:5. doi: 10.12688/wellcomeopenres.13387.2. eCollection 2018.


Metabolic implications of hypoxia and pseudohypoxia in pheochromocytoma and paraganglioma.

Kluckova K, Tennant DA.

Cell Tissue Res. 2018 May;372(2):367-378. doi: 10.1007/s00441-018-2801-6. Epub 2018 Feb 15. Review.


Combined Analysis of NMR and MS Spectra (CANMS).

Chong M, Jayaraman A, Marin S, Selivanov V, de Atauri Carulla PR, Tennant DA, Cascante M, Günther UL, Ludwig C.

Angew Chem Int Ed Engl. 2017 Apr 3;56(15):4140-4144. doi: 10.1002/anie.201611634. Epub 2017 Mar 8.


Metabolic differences between cold stored and machine perfused porcine kidneys: A 1H NMR based study.

Nath J, Smith TB, Patel K, Ebbs SR, Hollis A, Tennant DA, Ludwig C, Ready AR.

Cryobiology. 2017 Feb;74:115-120. doi: 10.1016/j.cryobiol.2016.11.006. Epub 2016 Dec 3.


Isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), fumarate hydratase (FH): three players for one phenotype in cancer?

Laurenti G, Tennant DA.

Biochem Soc Trans. 2016 Aug 15;44(4):1111-6. doi: 10.1042/BST20160099. Review.


(13)C glucose labelling studies using 2D NMR are a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys.

Nath J, Smith T, Hollis A, Ebbs S, Canbilen SW, Tennant DA, Ready AR, Ludwig C.

Transplant Res. 2016 Aug 5;5:7. doi: 10.1186/s13737-016-0037-0. eCollection 2016.


Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma.

McNee G, Eales KL, Wei W, Williams DS, Barkhuizen A, Bartlett DB, Essex S, Anandram S, Filer A, Moss PA, Pratt G, Basu S, Davies CC, Tennant DA.

Leukemia. 2017 Feb;31(2):373-381. doi: 10.1038/leu.2016.187. Epub 2016 Jul 11.


Probing Cancer Cell Metabolism Using NMR Spectroscopy.

Hollinshead KE, Williams DS, Tennant DA, Ludwig C.

Adv Exp Med Biol. 2016;899:89-111. doi: 10.1007/978-3-319-26666-4_6. Review.


Mitochondrial metabolic remodeling in response to genetic and environmental perturbations.

Hollinshead KE, Tennant DA.

Wiley Interdiscip Rev Syst Biol Med. 2016 Jul;8(4):272-85. doi: 10.1002/wsbm.1334. Epub 2016 May 19. Review.


Hypoxia and metabolic adaptation of cancer cells.

Eales KL, Hollinshead KE, Tennant DA.

Oncogenesis. 2016 Jan 25;5:e190. doi: 10.1038/oncsis.2015.50. Review.


Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism.

Lussey-Lepoutre C, Hollinshead KE, Ludwig C, Menara M, Morin A, Castro-Vega LJ, Parker SJ, Janin M, Martinelli C, Ottolenghi C, Metallo C, Gimenez-Roqueplo AP, Favier J, Tennant DA.

Nat Commun. 2015 Nov 2;6:8784. doi: 10.1038/ncomms9784.


Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma.

Ludwig C, Williams DS, Bartlett DB, Essex SJ, McNee G, Allwood JW, Jewell E, Barkhuisen A, Parry H, Anandram S, Nicolson P, Gardener C, Seymour F, Basu S, Dunn WB, Moss PA, Pratt G, Tennant DA.

Blood Cancer J. 2015 Oct 16;5:e359. doi: 10.1038/bcj.2015.85. No abstract available.


A roadmap for interpreting (13)C metabolite labeling patterns from cells.

Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM.

Curr Opin Biotechnol. 2015 Aug;34:189-201. doi: 10.1016/j.copbio.2015.02.003. Epub 2015 Feb 28. Review.

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