Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Sci Rep. 2017 Aug 25;7(1):9529. doi: 10.1038/s41598-017-08779-0.

Tau plasma levels in subjective cognitive decline: Results from the DELCODE study.

Author information

1
Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany. stephan.mueller@med.uni-tuebingen.de.
2
Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
3
German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
4
Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany.
5
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
6
German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
7
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
8
German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
9
Department of Neuropsychiatry, Charité - Universitätsmedizin Berlin & Berlin Institute of Health, Berlin, Germany.
10
Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München, Munich, Germany.
11
Department of Neurology, University Hospital Bonn, Bonn, Germany.
12
Charité - Universitätsmedizin Berlin, Institute of Psychiatry and Psychotherapy, CBF, Berlin, Germany.
13
Charité - Universitätsmedizin Berlin, Institute of Neuropathology, Berlin, Germany.
14
Department for Neurodegenerative Diseases and Gerontopsychiatry, University Hospital Bonn, Bonn, Germany.
15
German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
16
Department of Psychiatry, University Hospital Bonn, Bonn, Germany.
17
German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany.
18
Department of Psychiatry and Psychotherapy, University Medical Center Goettingen (UMG), Goettingen, Germany.
19
Department of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany.

Abstract

Previous studies have demonstrated increased tau plasma levels in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) due to AD. Much less is known whether increased tau plasma levels can already be detected in the pre-MCI stage of subjective cognitive decline (SCD). In the present study we measured tau plasma levels in 111 SCD patients and 134 age- and gender-matched cognitively healthy controls participating in the DZNE (German Center for Neurodegenerative Diseases) longitudinal study on cognition and dementia (DELCODE). Tau plasma levels were measured using ultra-sensitive, single-molecule array (Simoa) technology. We found no significant different tau plasma levels in SCD (3.4 pg/ml) compared with healthy controls (3.6 pg/ml) after controlling for age, gender, and education (p = 0.137). In addition, tau plasma levels did not correlate with Aβ42 (r = 0.073; p = 0.634), tau (r = -0.179; p = 0.240), and p-tau181 (r = -0.208; p = 0.171) cerebrospinal fluid (CSF) levels in a subgroup of 45 SCD patients with available CSF. In conclusion, plasma tau is not increased in SCD patients. In addition, the lack of correlation between tau in plasma and CSF in the examined cohort suggests that tau levels are affected by different factors in both biofluids.

PMID:
28842559
PMCID:
PMC5573353
DOI:
10.1038/s41598-017-08779-0
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center