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Trends Neurosci. 2018 Jan;41(1):31-46. doi: 10.1016/j.tins.2017.11.001. Epub 2017 Dec 6.

Bioprinting for Neural Tissue Engineering.

Author information

1
Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA; These authors contributed equally.
2
Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA; These authors contributed equally.
3
Departement of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269, USA.
4
Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA; Department of Mechanical Engineering, University of Connecticut, Storrs, CT 06269, USA; Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA; Institute for Collaboration on Health, Intervention, and Policy, University of Connecticut, Storrs, CT 06269, USA; The Connecticut Institute for the Brain and Cognitive Sciences, University of Connecticut, Storrs, CT 06269, USA. Electronic address: savas.tasoglu@uconn.edu.

Abstract

Bioprinting is a method by which a cell-encapsulating bioink is patterned to create complex tissue architectures. Given the potential impact of this technology on neural research, we review the current state-of-the-art approaches for bioprinting neural tissues. While 2D neural cultures are ubiquitous for studying neural cells, 3D cultures can more accurately replicate the microenvironment of neural tissues. By bioprinting neuronal constructs, one can precisely control the microenvironment by specifically formulating the bioink for neural tissues, and by spatially patterning cell types and scaffold properties in three dimensions. We review a range of bioprinted neural tissue models and discuss how they can be used to observe how neurons behave, understand disease processes, develop new therapies and, ultimately, design replacement tissues.

KEYWORDS:

biofabrication; bioprinting; neural tissue engineering; neurological disease; regenerative medicine

PMID:
29223312
DOI:
10.1016/j.tins.2017.11.001
[Indexed for MEDLINE]

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