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Items: 1 to 20 of 76


Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.

Gao R, Chakraborty A, Geater C, Pradhan S, Gordon KL, Snowden J, Yuan S, Dickey AS, Choudhary S, Ashizawa T, Ellerby LM, La Spada AR, Thompson LM, Hazra TK, Sarkar PS.

Elife. 2019 Apr 17;8. pii: e42988. doi: 10.7554/eLife.42988.


Excision release of 5?hydroxycytosine oxidatively induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation.

Hosoki K, Jaruga P, Itazawa T, Aguilera-Aguirre L, Coskun E, Hazra TK, Boldogh I, Dizdaroglu M, Sur S.

Clin Exp Allergy. 2018 Dec;48(12):1676-1687. doi: 10.1111/cea.13284. Epub 2018 Nov 5.


Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA.

Hao W, Qi T, Pan L, Wang R, Zhu B, Aguilera-Aguirre L, Radak Z, Hazra TK, Vlahopoulos SA, Bacsi A, Brasier AR, Ba X, Boldogh I.

Redox Biol. 2018 Sep;18:43-53. doi: 10.1016/j.redox.2018.06.002. Epub 2018 Jun 12.


The Pivotal Role of DNA Repair in Infection Mediated-Inflammation and Cancer.

Sahan AZ, Hazra TK, Das S.

Front Microbiol. 2018 Apr 11;9:663. doi: 10.3389/fmicb.2018.00663. eCollection 2018. Review.


Feeling Stressed under the Sun? RPA1 Acetylation to the Rescue.

Chakravarti D, Hazra TK.

Cell Rep. 2017 Aug 29;20(9):1995-1996. doi: 10.1016/j.celrep.2017.08.045.


Innate mechanism of pollen- and cat dander-induced oxidative stress and DNA damage in the airways.

Hosoki K, Redding D, Itazawa T, Chakraborty A, Tapryal N, Qian S, Qi H, Aguilera-Aguirre L, Brasier AR, Phani VS, Hazra TK, Boldogh I, Sur S.

J Allergy Clin Immunol. 2017 Nov;140(5):1436-1439.e5. doi: 10.1016/j.jaci.2017.04.044. Epub 2017 Jun 2. No abstract available.


PEG-functionalized zinc oxide nanoparticles induce apoptosis in breast cancer cells through reactive oxygen species-dependent impairment of DNA damage repair enzyme NEIL2.

Chakraborti S, Chakraborty S, Saha S, Manna A, Banerjee S, Adhikary A, Sarwar S, Hazra TK, Das T, Chakrabarti P.

Free Radic Biol Med. 2017 Feb;103:35-47. doi: 10.1016/j.freeradbiomed.2016.11.048. Epub 2016 Dec 7.


Oxidized Guanine Base Lesions Function in 8-Oxoguanine DNA Glycosylase-1-mediated Epigenetic Regulation of Nuclear Factor κB-driven Gene Expression.

Pan L, Zhu B, Hao W, Zeng X, Vlahopoulos SA, Hazra TK, Hegde ML, Radak Z, Bacsi A, Brasier AR, Ba X, Boldogh I.

J Biol Chem. 2016 Dec 2;291(49):25553-25566. Epub 2016 Oct 18.


Classical non-homologous end-joining pathway utilizes nascent RNA for error-free double-strand break repair of transcribed genes.

Chakraborty A, Tapryal N, Venkova T, Horikoshi N, Pandita RK, Sarker AH, Sarkar PS, Pandita TK, Hazra TK.

Nat Commun. 2016 Oct 5;7:13049. doi: 10.1038/ncomms13049.


Myeloid differentiation protein 2 facilitates pollen- and cat dander-induced innate and allergic airway inflammation.

Hosoki K, Boldogh I, Aguilera-Aguirre L, Sun Q, Itazawa T, Hazra T, Brasier AR, Kurosky A, Sur S.

J Allergy Clin Immunol. 2016 May;137(5):1506-1513.e2. doi: 10.1016/j.jaci.2015.09.036. Epub 2015 Nov 14.


Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation.

Chakraborty A, Wakamiya M, Venkova-Canova T, Pandita RK, Aguilera-Aguirre L, Sarker AH, Singh DK, Hosoki K, Wood TG, Sharma G, Cardenas V, Sarkar PS, Sur S, Pandita TK, Boldogh I, Hazra TK.

J Biol Chem. 2015 Oct 9;290(41):24636-48. doi: 10.1074/jbc.M115.658146. Epub 2015 Aug 5.


Amphotericin B and anidulafungin directly interact with DNA and induce oxidative damage in the mammalian genome.

Mandal SM, Chakraborty A, Hossain M, Mahata D, Porto WF, Chakraborty R, Mukhopadhyay CK, Franco OL, Hazra TK, Basak A.

Mol Biosyst. 2015 Sep;11(9):2551-9. doi: 10.1039/c5mb00366k. Epub 2015 Jul 21.


The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: DOMINANT NEGATIVE FUNCTION OF THE CTD.

Hegde PM, Dutta A, Sengupta S, Mitra J, Adhikari S, Tomkinson AE, Li GM, Boldogh I, Hazra TK, Mitra S, Hegde ML.

J Biol Chem. 2015 Aug 21;290(34):20919-33. doi: 10.1074/jbc.M115.642918. Epub 2015 Jul 1.


Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease.

Suganya R, Chakraborty A, Miriyala S, Hazra TK, Izumi T.

DNA Repair (Amst). 2015 Mar;27:40-8. doi: 10.1016/j.dnarep.2015.01.003. Epub 2015 Jan 16.


The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.

Chatterjee A, Saha S, Chakraborty A, Silva-Fernandes A, Mandal SM, Neves-Carvalho A, Liu Y, Pandita RK, Hegde ML, Hegde PM, Boldogh I, Ashizawa T, Koeppen AH, Pandita TK, Maciel P, Sarkar PS, Hazra TK.

PLoS Genet. 2015 Jan 29;11(1):e1004749. doi: 10.1371/journal.pgen.1004749. eCollection 2015 Jan.


Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3.

Gao R, Liu Y, Silva-Fernandes A, Fang X, Paulucci-Holthauzen A, Chatterjee A, Zhang HL, Matsuura T, Choudhary S, Ashizawa T, Koeppen AH, Maciel P, Hazra TK, Sarkar PS.

PLoS Genet. 2015 Jan 15;11(1):e1004834. doi: 10.1371/journal.pgen.1004834. eCollection 2015 Jan.


Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway.

Aguilera-Aguirre L, Bacsi A, Radak Z, Hazra TK, Mitra S, Sur S, Brasier AR, Ba X, Boldogh I.

J Immunol. 2014 Nov 1;193(9):4643-53. doi: 10.4049/jimmunol.1401625. Epub 2014 Sep 29.


Controlling resistant bacteria with a novel class of β-lactamase inhibitor peptides: from rational design to in vivo analyses.

Mandal SM, Migliolo L, Silva ON, Fensterseifer IC, Faria-Junior C, Dias SC, Basak A, Hazra TK, Franco OL.

Sci Rep. 2014 Aug 11;4:6015. doi: 10.1038/srep06015.


MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.

Gupta A, Hunt CR, Hegde ML, Chakraborty S, Chakraborty S, Udayakumar D, Horikoshi N, Singh M, Ramnarain DB, Hittelman WN, Namjoshi S, Asaithamby A, Hazra TK, Ludwig T, Pandita RK, Tyler JK, Pandita TK.

Cell Rep. 2014 Jul 10;8(1):177-89. doi: 10.1016/j.celrep.2014.05.044. Epub 2014 Jun 19. Erratum in: Cell Rep. 2014 Jul 10;8(1):319.


Challenges and future prospects of antibiotic therapy: from peptides to phages utilization.

Mandal SM, Roy A, Ghosh AK, Hazra TK, Basak A, Franco OL.

Front Pharmacol. 2014 May 13;5:105. doi: 10.3389/fphar.2014.00105. eCollection 2014. Review.

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