Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Neurobiol Dis. 2019 Jan;121:95-105. doi: 10.1016/j.nbd.2018.09.022. Epub 2018 Sep 24.

TSPO and amyloid deposits in sub-regions of the hippocampus in the 3xTgAD mouse model of Alzheimer's disease.

Author information

1
Division of Adult Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland.
2
Normandie Univ, UNICAEN, CERMN, F-14032 Caen, France.
3
Normandie Univ, UNICAEN, CERMN, F-14032 Caen, France; Department of Nuclear Medicine, CHU Cote de Nacre, 14000 Caen, France.
4
ANSTO LifeSciences, Australian Nuclear Science and Technology Organisation, New Illawarra Road, Sydney, NSW 2234, Australia.
5
Division of Geriatric Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland; Department of Psychiatry, University of Geneva, Switzerland.
6
Division of Adult Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland; INSERM Unit 1039, J. Fourier University, La Tronche, France.
7
Division of Geriatric Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland.
8
Division of Adult Psychiatry, Department of Mental Health and Psychiatry, University Hospitals of Geneva, Switzerland; Department of Psychiatry, University of Geneva, Switzerland. Electronic address: Philippe.millet@hcuge.ch.

Abstract

The involvement of the 18kDa translocator protein (TSPO), a marker of neuroinflammation, in Alzheimer's disease (AD) remains controversial. In the present report, we used [125I]-CLINDE, a SPECT TSPO radiotracer never before used in AD, and we investigated the relationship between TSPO and amyloid plaque density (using [125I]-DRM106) in a triple transgenic mouse model of AD (3xTgAD, APPSWE, PS1M146V and TauP301L). Our results show that TSPO increases appear before those of amyloid deposits. Moreover, the different parts of the hippocampus are differentially affected. Indeed, for both TSPO and amyloid, the subiculum is affected earlier and the ventral hippocampus later than the dorsal hippocampus. In the subiculum and the dorsal hippocampus of 3xTgAD mice, a positive correlation between TSPO and of amyloid deposit levels is observed. This data supports the hypothesis that TSPO could be used as a predictive marker of amyloid pathology. In addition, our immunohistochemical data shows a segregation of TSPO in the hippocampus and immunofluorescence imaging revealed a mainly microglial origin of the TSPO expression. Thus, imaging TSPO with CLINDE may be a good alternative to PET radiotracers.

KEYWORDS:

3xTgAD; Alzheimer’s disease; CLINDE; DRM106; Neuroinflammation; TSPO

PMID:
30261283
DOI:
10.1016/j.nbd.2018.09.022

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center