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TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway.
Liu Y, Tao S, Liao L, Li Y, Li H, Li Z, Lin L, Wan X, Yang X, Chen L. Liu Y, et al. Nat Commun. 2020 Jan 17;11(1):348. doi: 10.1038/s41467-019-14190-2. Nat Commun. 2020. PMID: 31953436 Free PMC article.
In contrast, depletion of TRIM25 leads to ER stress and attenuates tumor cell growth in vitro and in vivo. ...Moreover, high TRIM25 expression correlates with poor patient survival in HCC. These findings reveal TRIM25 as a regulator of ER homeostasis and a po …
In contrast, depletion of TRIM25 leads to ER stress and attenuates tumor cell growth in vitro and in vivo. ...Moreover, high TRIM2 …
TRIM25: A central factor in breast cancer.
Tecalco-Cruz AC, Abraham-Juárez MJ, Solleiro-Villavicencio H, Ramírez-Jarquín JO. Tecalco-Cruz AC, et al. World J Clin Oncol. 2021 Aug 24;12(8):646-655. doi: 10.5306/wjco.v12.i8.646. World J Clin Oncol. 2021. PMID: 34513598 Free PMC article. Review.
TRIM25 is emerging as a central factor in breast cancer due to its regulation and function. In particular, it has been shown that: (1) Estrogens modulate TRIM25 gene expression; (2) TRIM25 has activity as an E3-ligase enzyme for ubiquitin; and (3) TRIM25 …
TRIM25 is emerging as a central factor in breast cancer due to its regulation and function. In particular, it has been shown that: (1 …
The role of TRIM25 in the occurrence and development of cancers and inflammatory diseases.
Rahimi-Tesiye M, Zaersabet M, Salehiyeh S, Jafari SZ. Rahimi-Tesiye M, et al. Biochim Biophys Acta Rev Cancer. 2023 Sep;1878(5):188954. doi: 10.1016/j.bbcan.2023.188954. Epub 2023 Jul 11. Biochim Biophys Acta Rev Cancer. 2023. PMID: 37437700 Review.
Given the importance of these proteins in pathogenesis, they can be considered as potential therapeutic targets for many diseases. TRIM25, as an E3-ubiquitin ligase, is involved in the development of various diseases and cellular mechanisms, including antiviral innate immu …
Given the importance of these proteins in pathogenesis, they can be considered as potential therapeutic targets for many diseases. TRIM25 …
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation.
Wu SF, Xia L, Shi XD, Dai YJ, Zhang WN, Zhao JM, Zhang W, Weng XQ, Lu J, Le HY, Tao SC, Zhu J, Chen Z, Wang YY, Chen S. Wu SF, et al. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14395-14404. doi: 10.1073/pnas.1918596117. Epub 2020 Jun 8. Proc Natl Acad Sci U S A. 2020. PMID: 32513696 Free PMC article.
We show that RIG-I could bind TRIM25 mRNA via its helicase domain and C-terminal regulatory domain, enhancing the stability of TRIM25 transcripts. ...Our results provide insight into the role of the RIG-I-TRIM25-ISGylation axis in myeloid differentiation....
We show that RIG-I could bind TRIM25 mRNA via its helicase domain and C-terminal regulatory domain, enhancing the stability of TRI …
TRIM25 and its emerging RNA-binding roles in antiviral defense.
Choudhury NR, Heikel G, Michlewski G. Choudhury NR, et al. Wiley Interdiscip Rev RNA. 2020 Jul;11(4):e1588. doi: 10.1002/wrna.1588. Epub 2020 Jan 28. Wiley Interdiscip Rev RNA. 2020. PMID: 31990130 Review.
Here, we review TRIM25's mechanisms and pathways in noninfected and infected cells. We also introduce models that explain how TRIM25 binding to RNA could modulate its functions and play part in the antiviral response. ...
Here, we review TRIM25's mechanisms and pathways in noninfected and infected cells. We also introduce models that explain how TRIM …
TRIM25 inhibits HBV replication by promoting HBx degradation and the RIG-I-mediated pgRNA recognition.
Song H, Xiao Q, Xu F, Wei Q, Wang F, Tan G. Song H, et al. Chin Med J (Engl). 2023 Apr 5;136(7):799-806. doi: 10.1097/CM9.0000000000002617. Chin Med J (Engl). 2023. PMID: 36975005 Free PMC article.
We previously reported that interferon (IFN)-induced tripartite motif-containing 25 (TRIM25) inhibited HBV replication by increasing the IFN expression, and this study aimed to further clarify the anti-HBV mechanism of TRIM25. METHODS: The TRIM25-mediated deg …
We previously reported that interferon (IFN)-induced tripartite motif-containing 25 (TRIM25) inhibited HBV replication by increasing …
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.
Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun L, Takeuchi O, Akira S, Chen Z, Inoue S, Jung JU. Gack MU, et al. Nature. 2007 Apr 19;446(7138):916-920. doi: 10.1038/nature05732. Nature. 2007. PMID: 17392790
Here we report that the amino-terminal caspase recruitment domains (CARDs) of RIG-I undergo robust ubiquitination induced by TRIM25 in mammalian cells. The carboxy-terminal SPRY domain of TRIM25 interacts with the N-terminal CARDs of RIG-I; this interaction effectiv …
Here we report that the amino-terminal caspase recruitment domains (CARDs) of RIG-I undergo robust ubiquitination induced by TRIM25 i …
TRIM25 in the Regulation of the Antiviral Innate Immunity.
Martín-Vicente M, Medrano LM, Resino S, García-Sastre A, Martínez I. Martín-Vicente M, et al. Front Immunol. 2017 Sep 22;8:1187. doi: 10.3389/fimmu.2017.01187. eCollection 2017. Front Immunol. 2017. PMID: 29018447 Free PMC article. Review.
TRIM25 is an E3 ubiquitin ligase enzyme that is involved in various cellular processes, including regulation of the innate immune response against viruses. ...In addition, the ability of TRIM25 to bind RNA may uncover new mechanisms by which this molecule regulates …
TRIM25 is an E3 ubiquitin ligase enzyme that is involved in various cellular processes, including regulation of the innate immune res …
Trim25 restricts rabies virus replication by destabilizing phosphoprotein.
Yuan Y, Fang A, Wang Z, Tian B, Zhang Y, Sui B, Luo Z, Li Y, Zhou M, Chen H, Fu ZF, Zhao L. Yuan Y, et al. Cell Insight. 2022 Sep 29;1(5):100057. doi: 10.1016/j.cellin.2022.100057. eCollection 2022 Oct. Cell Insight. 2022. PMID: 37193556 Free PMC article.
Recent studies have shown that Trim25 can bind and degrade viral proteins, suggesting a different mechanism of Trim25 on its antiviral effects. ...Moreover, expression of Trim25 limited RABV replication in cultured cells. Overexpression of Trim25 cause …
Recent studies have shown that Trim25 can bind and degrade viral proteins, suggesting a different mechanism of Trim25 on its a …
Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers.
Azuma K, Inoue S. Azuma K, et al. Cells. 2022 Aug 8;11(15):2464. doi: 10.3390/cells11152464. Cells. 2022. PMID: 35954308 Free PMC article. Review.
Estrogen-responsive finger protein (Efp), a member of the TRIM family proteins, also known as TRIM25, was originally identified as a protein induced by estrogen and plays critical roles in promoting endocrine-related cancers, including breast cancer, endometrial cancer, an …
Estrogen-responsive finger protein (Efp), a member of the TRIM family proteins, also known as TRIM25, was originally identified as a …
416 results