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886 results

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Berberine ameliorates depression-like behavior in CUMS mice by activating TPH1 and inhibiting IDO1-associated with tryptophan metabolism.
Ge PY, Qu SY, Ni SJ, Yao ZY, Qi YY, Zhao X, Guo R, Yang NY, Zhang QC, Zhu HX. Ge PY, et al. Phytother Res. 2023 Jan;37(1):342-357. doi: 10.1002/ptr.7616. Epub 2022 Sep 11. Phytother Res. 2023. PMID: 36089660
Moreover, berberine induced retraction of the abnormal neurotransmitters and metabolomics assays revealed that berberine promoted tryptophan biotransformation into serotonin and inhibited the kynurenine metabolism pathway, which was attributed to the potential agonist of tryptoph …
Moreover, berberine induced retraction of the abnormal neurotransmitters and metabolomics assays revealed that berberine promoted tryptophan …
The ever-changing roles of serotonin.
Jones LA, Sun EW, Martin AM, Keating DJ. Jones LA, et al. Int J Biochem Cell Biol. 2020 Aug;125:105776. doi: 10.1016/j.biocel.2020.105776. Epub 2020 May 29. Int J Biochem Cell Biol. 2020. PMID: 32479926 Review.
In mammals, serotonin is synthesized from the essential amino acid tryptophan by the rate-limiting enzyme tryptophan hydroxylase (TPH), for which there are two isoforms expressed in distinct cell types throughout the body. Tph1 is mainly expressed by specialized gut endocr …
In mammals, serotonin is synthesized from the essential amino acid tryptophan by the rate-limiting enzyme tryptophan hydroxylase (TPH), for …
Association between the TPH1 A218C polymorphism and antidepressant response: evidence from an updated ethnicity, antidepressant-specific, and ethnicity-antidepressant interaction meta-analysis.
Zhao X, Huang Y, Li D, Han C, Kan Q. Zhao X, et al. Psychiatr Genet. 2015 Feb;25(1):1-8. doi: 10.1097/YPG.0000000000000070. Psychiatr Genet. 2015. PMID: 25419635 Review.
BACKGROUND: Several studies have investigated the potential association between genetic polymorphisms of tryptophan hydroxylase 1 (TPH1) and antidepressant response. However, the results are inconsistent and inconclusive. Our aim was to assess the association of the TPH …
BACKGROUND: Several studies have investigated the potential association between genetic polymorphisms of tryptophan hydroxylase 1 (TPH1 …
TPH1 and 5-HT(7) Receptor Overexpression Leading to Gemcitabine-Resistance Requires Non-Canonical Permissive Action of EZH2 in Pancreatic Ductal Adenocarcinoma.
Chaudhary P, Guragain D, Chang JH, Kim JA. Chaudhary P, et al. Cancers (Basel). 2021 Oct 22;13(21):5305. doi: 10.3390/cancers13215305. Cancers (Basel). 2021. PMID: 34771469 Free PMC article.
In aggressive PANC-1 and MIA PaCa-2 cells, knock-down (KD) of EZH2, TPH1, or HTR7 induced a decrease in CSCs and recovery from gemcitabine resistance, while preconditioning of less aggressive Capan-1 cells with 5-HT induced gemcitabine resistance with increased expression …
In aggressive PANC-1 and MIA PaCa-2 cells, knock-down (KD) of EZH2, TPH1, or HTR7 induced a decrease in CSCs and recovery from gemcit …
Glutamine increases stability of TPH1 mRNA via p38 mitogen-activated kinase in mouse mastocytoma cells.
Park H, Lee CW, Kang J, Sadra A, Huh SO. Park H, et al. Mol Biol Rep. 2023 Jan;50(1):267-277. doi: 10.1007/s11033-022-07693-7. Epub 2022 Nov 4. Mol Biol Rep. 2023. PMID: 36331742 Free PMC article.
GLN-treated cells exhibited a robust increase in TPH1 mRNA after a 6 h exposure to GLN. 6-Diazo-5-oxo-L-norleucine (DON), a glutamine-utilizing glutaminase inhibitor, significantly inhibited the GLN-induction of TPH1 mRNA. ...We provide evidence that TPH1 mRN …
GLN-treated cells exhibited a robust increase in TPH1 mRNA after a 6 h exposure to GLN. 6-Diazo-5-oxo-L-norleucine (DON), a glutamine …
TPH1 A218C polymorphism and temperament in major depression.
Andre K, Kampman O, Viikki M, Illi A, Setälä-Soikkeli E, Poutanen O, Mononen N, Leinonen E, Lehtimäki T. Andre K, et al. BMC Psychiatry. 2013 Apr 18;13:118. doi: 10.1186/1471-244X-13-118. BMC Psychiatry. 2013. PMID: 23597148 Free PMC article.
In the analysis model, treatment response was used as a covariate and TPH1 genotype as a factor. A post hoc analysis for an interaction between remission status and TPH1 A218C genotype at endpoint HA level was also performed. RESULTS: The number of TPH1 A-all …
In the analysis model, treatment response was used as a covariate and TPH1 genotype as a factor. A post hoc analysis for an interacti …
TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients.
Snarska J, Fiedorowicz E, Rozmus D, Wroński K, Latacz M, Kordulewska N, Płomiński J, Grzybowski R, Savelkoul HFJ, Kostyra E, Cieślińska A. Snarska J, et al. BMC Gastroenterol. 2021 Nov 12;21(1):426. doi: 10.1186/s12876-021-02012-z. BMC Gastroenterol. 2021. PMID: 34772352 Free PMC article.
This study aimed to explore the association of a rs211105 (T/G) polymorphism in TPH1 gene with tryptophan hydroxylase 1 concentrations in blood serum in a population of acute pancreatitis patients, and to investigate this association with acute pancreatitis susceptibility. …
This study aimed to explore the association of a rs211105 (T/G) polymorphism in TPH1 gene with tryptophan hydroxylase 1 concentration …
Association between TPH1 polymorphisms and the risk of suicide behavior: An updated meta-analysis of 18,398 individuals.
Genis-Mendoza AD, Hernández-Díaz Y, González-Castro TB, Tovilla-Zárate CA, Castillo-Avila RG, López-Narváez ML, Ramos-Méndez MÁ, Nicolini H. Genis-Mendoza AD, et al. Front Psychiatry. 2022 Jul 19;13:932135. doi: 10.3389/fpsyt.2022.932135. eCollection 2022. Front Psychiatry. 2022. PMID: 35928776 Free PMC article.
OBJECTIVES: We aimed to examine the association of TPH1 polymorphisms with the risk of suicide behavior (SB). DESIGN: Systematic review and meta-analysis. ...Subgroup analyses, heterogeneity analyses, and publication bias were also tested in this meta-analysis. RESULTS: Th …
OBJECTIVES: We aimed to examine the association of TPH1 polymorphisms with the risk of suicide behavior (SB). DESIGN: Systematic revi …
Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan.
Chen DQ, Cao G, Chen H, Argyopoulos CP, Yu H, Su W, Chen L, Samuels DC, Zhuang S, Bayliss GP, Zhao S, Yu XY, Vaziri ND, Wang M, Liu D, Mao JR, Ma SX, Zhao J, Zhang Y, Shang YQ, Kang H, Ye F, Cheng XH, Li XR, Zhang L, Meng MX, Guo Y, Zhao YY. Chen DQ, et al. Nat Commun. 2019 Apr 1;10(1):1476. doi: 10.1038/s41467-019-09329-0. Nat Commun. 2019. PMID: 30931940 Free PMC article.
Peptide OM-LV20 protects astrocytes against oxidative stress via the 'PAC1R/JNK/TPH1' axis.
Yin S, Pang A, Liu C, Li Y, Liu N, Li S, Li C, Sun H, Fu Z, Wang Y, Zhang Y, Yang M, Sun J, Wang Y, Yang X. Yin S, et al. J Biol Chem. 2022 Oct;298(10):102429. doi: 10.1016/j.jbc.2022.102429. Epub 2022 Aug 28. J Biol Chem. 2022. PMID: 36037970 Free PMC article.
Here, we used primary astrocyte culture, quantitative real-time PCR, double immunofluorescence assay, lentiviral infection, cell viability analysis, Western blotting, and other biochemical experiments to explore the protective mechanism of peptide OM-LV20, which previously exhibi …
Here, we used primary astrocyte culture, quantitative real-time PCR, double immunofluorescence assay, lentiviral infection, cell viability a …
886 results