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TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.
Kaminker PG, Kim SH, Taylor RD, Zebarjadian Y, Funk WD, Morin GB, Yaswen P, Campisi J. Kaminker PG, et al. J Biol Chem. 2001 Sep 21;276(38):35891-9. doi: 10.1074/jbc.M105968200. Epub 2001 Jul 13. J Biol Chem. 2001. PMID: 11454873 Free article.
TANK2 is encoded by a 66-kilobase pair gene (TNKS2) containing 28 exons, which express a 6.7-kilobase pair mRNA and a 1166-amino acid protein. ...In contrast to TANK1, however, TANK2 caused rapid cell death when highly overexpressed. TANK2-induced death featu …
TANK2 is encoded by a 66-kilobase pair gene (TNKS2) containing 28 exons, which express a 6.7-kilobase pair mRNA and a 1166-amino acid …
The expression of gene transcripts of telomere-associated genes in human breast cancer: correlation with clinico-pathological parameters and clinical outcome.
Salhab M, Jiang WG, Newbold RF, Mokbel K. Salhab M, et al. Breast Cancer Res Treat. 2008 May;109(1):35-46. doi: 10.1007/s10549-007-9622-8. Epub 2007 Jul 7. Breast Cancer Res Treat. 2008. PMID: 17616810
METHODS: One hundred and twenty seven tumour tissues and 33 normal tissues were analyzed. Levels of transcription of hTERT, hTR, TRF1, TRF2, TANK1, TANK2, POT1, TIN2, EST1, and TEP1 were determined using real-time quantitative PCR. ...CONCLUSIONS: Genes encoding telomere-a …
METHODS: One hundred and twenty seven tumour tissues and 33 normal tissues were analyzed. Levels of transcription of hTERT, hTR, TRF1, TRF2, …
TIN2 mediates functions of TRF2 at human telomeres.
Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J. Kim SH, et al. J Biol Chem. 2004 Oct 15;279(42):43799-804. doi: 10.1074/jbc.M408650200. Epub 2004 Aug 3. J Biol Chem. 2004. PMID: 15292264 Free article.
Mammalian TRF1 and TRF2 bind the double-stranded telomeric repeat sequence and in turn are bound by TIN2, TANK1, TANK2, and hRAP1. TRF1 is a negative regulator of telomere length in telomerase-positive cells, whereas TRF2 is important for telomere capping. ...
Mammalian TRF1 and TRF2 bind the double-stranded telomeric repeat sequence and in turn are bound by TIN2, TANK1, TANK2, and hRAP1. TR …
Telomerase activation without shortening of telomeric 3'-overhang is a poor prognostic factor in human colorectal cancer.
Kojima K, Hiyama E, Otani K, Ohtaki M, Fukuba I, Fukuda E, Sueda T, Hiyama K. Kojima K, et al. Cancer Sci. 2011 Feb;102(2):330-5. doi: 10.1111/j.1349-7006.2010.01786.x. Epub 2010 Nov 26. Cancer Sci. 2011. PMID: 21108695 Free article.
The expression levels of eight TBP genes (TRF1, TRF2, TIN2, TANK1, TANK2, POT1, RAP1 and TPP1) were analyzed. Among the 106 cases, 35 cases had shortened telomeres (<7 kb), 15 had shortened 3'-OH (3'-OH length ratio of cancer/NCM <0.5) and 88 were classified as telom …
The expression levels of eight TBP genes (TRF1, TRF2, TIN2, TANK1, TANK2, POT1, RAP1 and TPP1) were analyzed. Among the 106 cases, 35 …
The expression of telomeric proteins and their probable regulation of telomerase during the differentiation of all-trans-retinoic acid-responsive and -resistant acute promyelocytic leukemia cells.
Sun J, Huang H, Zhu Y, Lan J, Li J, Lai X, Yu J. Sun J, et al. Int J Hematol. 2005 Oct;82(3):215-23. doi: 10.1532/IJH97.A10420. Int J Hematol. 2005. PMID: 16207594
Using all-trans-retinoic acid (ATRA)-sensitive and -resistant APL cell lines NB4, NB4-R1, and NB4-R2, we analyzed a panel of telomeric proteins, including TRF1, PINX1, TANK1, and TANK2, at the messenger RNA (mRNA) and protein expression levels during the differentiation of …
Using all-trans-retinoic acid (ATRA)-sensitive and -resistant APL cell lines NB4, NB4-R1, and NB4-R2, we analyzed a panel of telomeric prote …