Format

Send to

Choose Destination

See 1 citation found by title matching your search:

Org Biomol Chem. 2013 Dec 21;11(47):8228-34. doi: 10.1039/c3ob41498a. Epub 2013 Oct 28.

Synthesis of nitric oxide probes with fluorescence lifetime sensitivity.

Author information

1
Department of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA. berezinm@mir.wustl.edu.

Abstract

We present the rationale, synthesis and evaluation of the first activatable fluorescent probe that utilizes fluorescence lifetime change for detection of nitric oxide. The new probe DAP-LT1 features a near-infrared polymethine skeleton with a diaminobenzene functionality incorporated into the meso-position. The probe is partially quenched, and upon reaction with nitric oxide shows an increase in the fluorescence lifetime from 1.08 ns to 1.24 ns.

PMID:
24166035
PMCID:
PMC3872128
DOI:
10.1039/c3ob41498a
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Royal Society of Chemistry Icon for PubMed Central
Loading ...
Support Center