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Year Number of Results
1964 1
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1972 153
1973 185
1974 224
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1980 421
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1982 459
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2001 379
2002 362
2003 379
2004 366
2005 315
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2007 411
2008 382
2009 336
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2011 328
2012 360
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18,139 results

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Page 1
Synaptosome proteomics.
Bai F, Witzmann FA. Bai F, et al. Subcell Biochem. 2007;43:77-98. doi: 10.1007/978-1-4020-5943-8_6. Subcell Biochem. 2007. PMID: 17953392 Free PMC article. Review.
More recently, the combination of the classical subcellular fractionation techniques for the isolation of synaptosomes from the brain with the various proteomic analyses has facilitated this effort. ...
More recently, the combination of the classical subcellular fractionation techniques for the isolation of synaptosomes from the brain …
Thirty years of synaptosome research.
Whittaker VP. Whittaker VP. J Neurocytol. 1993 Sep;22(9):735-42. doi: 10.1007/BF01181319. J Neurocytol. 1993. PMID: 7903689 Review.
Detached synapses (synaptosomes), first isolated by the author in 1958 and identified as such in 1960, are sealed presynaptic nerve terminals often with a portion of the target cell--sometimes amounting to a complete dendritic spine--adhering to their external surface. ...
Detached synapses (synaptosomes), first isolated by the author in 1958 and identified as such in 1960, are sealed presynaptic nerve t …
Synaptosome preparations.
Whittaker VP. Whittaker VP. J Neurochem. 1988 Jan;50(1):324-5. doi: 10.1111/j.1471-4159.1988.tb13270.x. J Neurochem. 1988. PMID: 3335849 No abstract available.
Quantitative proteomics of synaptosome S-nitrosylation in Alzheimer's disease.
Wijasa TS, Sylvester M, Brocke-Ahmadinejad N, Schwartz S, Santarelli F, Gieselmann V, Klockgether T, Brosseron F, Heneka MT. Wijasa TS, et al. J Neurochem. 2020 Mar;152(6):710-726. doi: 10.1111/jnc.14870. Epub 2019 Oct 21. J Neurochem. 2020. PMID: 31520481 Free article.
In the long term, such changes could provide new insight into patho-mechanisms as well as biomarker candidates from the early stages of disease progression. This study investigated S-nitrosylation in synaptosomal proteins isolated from APP/PS1 model mice in comparison to w …
In the long term, such changes could provide new insight into patho-mechanisms as well as biomarker candidates from the early stages of dise …
Fast and efficient synaptosome isolation and post-synaptic density enrichment from hiPSC-motor neurons by biochemical sub-cellular fractionation.
Rajkumar S, Böckers TM, Catanese A. Rajkumar S, et al. STAR Protoc. 2023 Mar 17;4(1):102061. doi: 10.1016/j.xpro.2023.102061. Epub 2023 Jan 25. STAR Protoc. 2023. PMID: 36853677 Free PMC article.
We describe here a time-efficient, in-house protocol for synaptosome isolation and enrichment of the post-synaptic density (PSD) from hiPSC-derived motor neurons. By using biochemical sub-cellular fractionation, the crude synaptosome is first isolated from the cytos …
We describe here a time-efficient, in-house protocol for synaptosome isolation and enrichment of the post-synaptic density (PSD) from …
The synaptosome as a model system for studying synaptic physiology.
Evans GJ. Evans GJ. Cold Spring Harb Protoc. 2015 May 1;2015(5):421-4. doi: 10.1101/pdb.top074450. Cold Spring Harb Protoc. 2015. PMID: 25934942
Synaptosomes can also be stimulated to release neurotransmitters and were used to discover a number of regulatory signaling pathways that fine-tune synaptic transmission. In the past decade, landmark proteomic studies of synaptosomes and synaptic vesicle preparation …
Synaptosomes can also be stimulated to release neurotransmitters and were used to discover a number of regulatory signaling pathways …
Synaptosome behaviour is unaffected by weak pulsed electromagnetic fields.
Aldinucci C, Carretta A, Maiorca S, Rossi V, Ciccoli L, Pessina GP. Aldinucci C, et al. Bioelectromagnetics. 2007 Sep;28(6):477-83. doi: 10.1002/bem.20322. Bioelectromagnetics. 2007. PMID: 17497690
The O(2) consumption remained unvaried in exposed synaptosomes at about 2 nM O(2)/min/mg proteins; ATP production was also unchanged. ...On the whole, our results indicate that the physiological behaviour of cortical synaptosomes is not affected by weak pulsed EMFs. …
The O(2) consumption remained unvaried in exposed synaptosomes at about 2 nM O(2)/min/mg proteins; ATP production was also unchanged. …
Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice.
Jin C, Lee Y, Kang H, Jeong K, Park J, Zhang Y, Kang HR, Ma R, Seong H, Kim Y, Jung H, Kim JY, Kim YK, Han K. Jin C, et al. Mol Brain. 2021 Feb 23;14(1):39. doi: 10.1186/s13041-021-00756-z. Mol Brain. 2021. PMID: 33622379 Free PMC article.
In our previous quantitative proteomic analysis, six up-regulated ribosomal proteins were identified in the striatal synaptosome of Shank3-overexpressing transgenic (TG) mice. In the present study, we validated the increased levels of RPLP1 and RPL36A in synaptosome …
In our previous quantitative proteomic analysis, six up-regulated ribosomal proteins were identified in the striatal synaptosome of S …
Critical Analysis of Particle Detection Artifacts in Synaptosome Flow Cytometry.
Hobson BD, Sims PA. Hobson BD, et al. eNeuro. 2019 Jun 12;6(3):ENEURO.0009-19.2019. doi: 10.1523/ENEURO.0009-19.2019. Print 2019 May/Jun. eNeuro. 2019. PMID: 31118205 Free PMC article.
To date, most flow cytometry studies of synaptosomes have relied on particle detection using forward scatter (FSC) measurements and size estimation with polystyrene (PS) bead standards. ...Our study highlights challenges and pitfalls in synaptosome flow cytometry an …
To date, most flow cytometry studies of synaptosomes have relied on particle detection using forward scatter (FSC) measurements and s …
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