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Neuron. 2015 Dec 2;88(5):957-972. doi: 10.1016/j.neuron.2015.10.037. Epub 2015 Nov 19.

Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes.

Author information

1
University of Lausanne, Department of Fundamental Neurosciences, 9 rue du Bugnon, 1005 Lausanne, Switzerland.
2
Department of Biomedicine, Physiological Institute, University of Basel, Pestalozzistrasse 20, 4056 Basel, Switzerland.
3
CNRS UPR 3212, University of Strasbourg, Institute of Cellular and Integrative Neurosciences, 67084 Strasbourg, France.
4
University of Lausanne, Department of Fundamental Neurosciences, 9 rue du Bugnon, 1005 Lausanne, Switzerland. Electronic address: nicolas.toni@unil.ch.

Abstract

Adult neurogenesis is regulated by the neurogenic niche, through mechanisms that remain poorly defined. Here, we investigated whether niche-constituting astrocytes influence the maturation of adult-born hippocampal neurons using two independent transgenic approaches to block vesicular release from astrocytes. In these models, adult-born neurons but not mature neurons showed reduced glutamatergic synaptic input and dendritic spine density that was accompanied with lower functional integration and cell survival. By taking advantage of the mosaic expression of transgenes in astrocytes, we found that spine density was reduced exclusively in segments intersecting blocked astrocytes, revealing an extrinsic, local control of spine formation. Defects in NMDA receptor (NMDAR)-mediated synaptic transmission and dendrite maturation were partially restored by exogenous D-serine, whose extracellular level was decreased in transgenic models. Together, these results reveal a critical role for adult astrocytes in local dendritic spine maturation, which is necessary for the NMDAR-dependent functional integration of newborn neurons.

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PMID:
26606999
DOI:
10.1016/j.neuron.2015.10.037
[Indexed for MEDLINE]
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