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Facilitated Diffusion Mechanisms in DNA Base Excision Repair and Transcriptional Activation.

Esadze A, Stivers JT.

Chem Rev. 2018 Oct 31. doi: 10.1021/acs.chemrev.8b00513. [Epub ahead of print]


N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA-dsDNA junctions.

Weiser BP, Rodriguez G, Cole PA, Stivers JT.

Nucleic Acids Res. 2018 Aug 21;46(14):7169-7178. doi: 10.1093/nar/gky525.


Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells.

Esadze A, Rodriguez G, Weiser BP, Cole PA, Stivers JT.

Nucleic Acids Res. 2017 Dec 1;45(21):12413-12424. doi: 10.1093/nar/gkx848.


Disordered N-Terminal Domain of Human Uracil DNA Glycosylase (hUNG2) Enhances DNA Translocation.

Rodriguez G, Esadze A, Weiser BP, Schonhoft JD, Cole PA, Stivers JT.

ACS Chem Biol. 2017 Sep 15;12(9):2260-2263. doi: 10.1021/acschembio.7b00521. Epub 2017 Aug 15.


Investigation of N-Terminal Phospho-Regulation of Uracil DNA Glycosylase Using Protein Semisynthesis.

Weiser BP, Stivers JT, Cole PA.

Biophys J. 2017 Jul 25;113(2):393-401. doi: 10.1016/j.bpj.2017.06.016.


AP-Endonuclease 1 Accelerates Turnover of Human 8-Oxoguanine DNA Glycosylase by Preventing Retrograde Binding to the Abasic-Site Product.

Esadze A, Rodriguez G, Cravens SL, Stivers JT.

Biochemistry. 2017 Apr 11;56(14):1974-1986. doi: 10.1021/acs.biochem.7b00017. Epub 2017 Mar 31.


Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.

Seamon KJ, Bumpus NN, Stivers JT.

Biochemistry. 2016 Nov 8;55(44):6087-6099. Epub 2016 Oct 27.


Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells.

Hansen EC, Ransom M, Hesselberth JR, Hosmane NN, Capoferri AA, Bruner KM, Pollack RA, Zhang H, Drummond MB, Siliciano JM, Siliciano R, Stivers JT.

Elife. 2016 Sep 20;5. pii: e18447. doi: 10.7554/eLife.18447.


Comparative Effects of Ions, Molecular Crowding, and Bulk DNA on the Damage Search Mechanisms of hOGG1 and hUNG.

Cravens SL, Stivers JT.

Biochemistry. 2016 Sep 20;55(37):5230-42. doi: 10.1021/acs.biochem.6b00482. Epub 2016 Sep 7.


SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity.

Seamon KJ, Sun Z, Shlyakhtenko LS, Lyubchenko YL, Stivers JT.

Nucleic Acids Res. 2015 Jul 27;43(13):6486-99. doi: 10.1093/nar/gkv633. Epub 2015 Jun 22.


Molecular crowding enhances facilitated diffusion of two human DNA glycosylases.

Cravens SL, Schonhoft JD, Rowland MM, Rodriguez AA, Anderson BG, Stivers JT.

Nucleic Acids Res. 2015 Apr 30;43(8):4087-97. doi: 10.1093/nar/gkv301. Epub 2015 Apr 6.


A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase.

Seamon KJ, Stivers JT.

J Biomol Screen. 2015 Jul;20(6):801-9. doi: 10.1177/1087057115575150. Epub 2015 Mar 9.


Electrostatic properties of complexes along a DNA glycosylase damage search pathway.

Cravens SL, Hobson M, Stivers JT.

Biochemistry. 2014 Dec 9;53(48):7680-92. doi: 10.1021/bi501011m. Epub 2014 Nov 26.


High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase.

Gajula KS, Huwe PJ, Mo CY, Crawford DJ, Stivers JT, Radhakrishnan R, Kohli RM.

Nucleic Acids Res. 2014 Sep;42(15):9964-75. doi: 10.1093/nar/gku689. Epub 2014 Jul 26.


Microscopic mechanism of DNA damage searching by hOGG1.

Rowland MM, Schonhoft JD, McKibbin PL, David SS, Stivers JT.

Nucleic Acids Res. 2014 Aug;42(14):9295-303. doi: 10.1093/nar/gku621. Epub 2014 Jul 12.


Small molecule inhibition of SAMHD1 dNTPase by tetramer destabilization.

Seamon KJ, Hansen EC, Kadina AP, Kashemirov BA, McKenna CE, Bumpus NN, Stivers JT.

J Am Chem Soc. 2014 Jul 16;136(28):9822-5. doi: 10.1021/ja5035717. Epub 2014 Jul 8.


Variola type IB DNA topoisomerase: DNA binding and supercoil unwinding using engineered DNA minicircles.

Anderson BG, Stivers JT.

Biochemistry. 2014 Jul 8;53(26):4302-15. doi: 10.1021/bi500571q. Epub 2014 Jun 26.


GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state.

Hansen EC, Seamon KJ, Cravens SL, Stivers JT.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1843-51. doi: 10.1073/pnas.1401706111. Epub 2014 Apr 21.


Correction to DNA translocation by human uracil DNA glycosylase: role of DNA phosphate charge.

Schonhoft JD, Kosowicz JG, Stivers JT.

Biochemistry. 2013 Nov 26;52(47):8599. doi: 10.1021/bi401512a. Epub 2013 Nov 14. No abstract available.


DNA translocation by human uracil DNA glycosylase: role of DNA phosphate charge.

Schonhoft JD, Kosowicz JG, Stivers JT.

Biochemistry. 2013 Apr 16;52(15):2526-35. doi: 10.1021/bi301561d. Epub 2013 Apr 2. Erratum in: Biochemistry. 2013 Nov 26;52(47):8599.

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