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J Biosci Bioeng. 2012 Feb;113(2):192-5. doi: 10.1016/j.jbiosc.2011.09.019. Epub 2011 Oct 26.

Stable disruption of ethanol production by deletion of the genes encoding alcohol dehydrogenase isozymes in Saccharomyces cerevisiae.

Author information

1
Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, 1-5 Yamadaoka, Suita, Osaka 565-0871, Japan.

Abstract

We analyzed the effects of the deletions of genes encoding alcohol dehydrogenase (ADH) isozymes of Saccharomyces cerevisiae. The decrease in ethanol production by ADH1 deletion alone could be partially compensated by the upregulation of other isozyme genes, while the deletion of all known ADH isozyme genes stably disrupted ethanol production.

PMID:
22033067
DOI:
10.1016/j.jbiosc.2011.09.019
[Indexed for MEDLINE]

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