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Items: 1 to 20 of 94

1.

Glutamate and GABA in autism spectrum disorder-a translational magnetic resonance spectroscopy study in man and rodent models.

Horder J, Petrinovic MM, Mendez MA, Bruns A, Takumi T, Spooren W, Barker GJ, Künnecke B, Murphy DG.

Transl Psychiatry. 2018 May 25;8(1):106. doi: 10.1038/s41398-018-0155-1.

2.

EU-AIMS Longitudinal European Autism Project (LEAP): the autism twin cohort.

Isaksson J, Tammimies K, Neufeld J, Cauvet É, Lundin K, Buitelaar JK, Loth E, Murphy DGM, Spooren W, Bölte S; EU-AIMS LEAP group.

Mol Autism. 2018 Apr 13;9:26. doi: 10.1186/s13229-018-0212-x. eCollection 2018.

3.

Drug development for neurodevelopmental disorders: lessons learned from fragile X syndrome.

Berry-Kravis EM, Lindemann L, Jønch AE, Apostol G, Bear MF, Carpenter RL, Crawley JN, Curie A, Des Portes V, Hossain F, Gasparini F, Gomez-Mancilla B, Hessl D, Loth E, Scharf SH, Wang PP, Von Raison F, Hagerman R, Spooren W, Jacquemont S.

Nat Rev Drug Discov. 2018 Apr;17(4):280-299. doi: 10.1038/nrd.2017.221. Epub 2017 Dec 8. Review.

PMID:
29217836
4.

Comprehensive analysis of two Shank3 and the Cacna1c mouse models of autism spectrum disorder.

Kabitzke PA, Brunner D, He D, Fazio PA, Cox K, Sutphen J, Thiede L, Sabath E, Hanania T, Alexandrov V, Rasmusson R, Spooren W, Ghosh A, Feliciano P, Biemans B, Benedetti M, Clayton AL.

Genes Brain Behav. 2018 Jan;17(1):4-22. doi: 10.1111/gbb.12405. Epub 2017 Sep 5.

PMID:
28753255
5.

The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation.

Charman T, Loth E, Tillmann J, Crawley D, Wooldridge C, Goyard D, Ahmad J, Auyeung B, Ambrosino S, Banaschewski T, Baron-Cohen S, Baumeister S, Beckmann C, Bölte S, Bourgeron T, Bours C, Brammer M, Brandeis D, Brogna C, de Bruijn Y, Chakrabarti B, Cornelissen I, Acqua FD, Dumas G, Durston S, Ecker C, Faulkner J, Frouin V, Garcés P, Ham L, Hayward H, Hipp J, Holt RJ, Isaksson J, Johnson MH, Jones EJH, Kundu P, Lai MC, D'ardhuy XL, Lombardo MV, Lythgoe DJ, Mandl R, Mason L, Meyer-Lindenberg A, Moessnang C, Mueller N, O'Dwyer L, Oldehinkel M, Oranje B, Pandina G, Persico AM, Ruggeri B, Ruigrok ANV, Sabet J, Sacco R, Cáceres ASJ, Simonoff E, Toro R, Tost H, Waldman J, Williams SCR, Zwiers MP, Spooren W, Murphy DGM, Buitelaar JK.

Mol Autism. 2017 Jun 23;8:27. doi: 10.1186/s13229-017-0145-9. eCollection 2017.

6.

The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders.

Loth E, Charman T, Mason L, Tillmann J, Jones EJH, Wooldridge C, Ahmad J, Auyeung B, Brogna C, Ambrosino S, Banaschewski T, Baron-Cohen S, Baumeister S, Beckmann C, Brammer M, Brandeis D, Bölte S, Bourgeron T, Bours C, de Bruijn Y, Chakrabarti B, Crawley D, Cornelissen I, Acqua FD, Dumas G, Durston S, Ecker C, Faulkner J, Frouin V, Garces P, Goyard D, Hayward H, Ham LM, Hipp J, Holt RJ, Johnson MH, Isaksson J, Kundu P, Lai MC, D'ardhuy XL, Lombardo MV, Lythgoe DJ, Mandl R, Meyer-Lindenberg A, Moessnang C, Mueller N, O'Dwyer L, Oldehinkel M, Oranje B, Pandina G, Persico AM, Ruigrok ANV, Ruggeri B, Sabet J, Sacco R, Cáceres ASJ, Simonoff E, Toro R, Tost H, Waldman J, Williams SCR, Zwiers MP, Spooren W, Murphy DGM, Buitelaar JK.

Mol Autism. 2017 Jun 23;8:24. doi: 10.1186/s13229-017-0146-8. eCollection 2017.

7.

Neuroimaging, Genetics, and Clinical Data Sharing in Python Using the CubicWeb Framework.

Grigis A, Goyard D, Cherbonnier R, Gareau T, Papadopoulos Orfanos D, Chauvat N, Di Mascio A, Schumann G, Spooren W, Murphy D, Frouin V.

Front Neuroinform. 2017 Mar 16;11:18. doi: 10.3389/fninf.2017.00018. eCollection 2017.

8.

Defining Precision Medicine Approaches to Autism Spectrum Disorders: Concepts and Challenges.

Loth E, Murphy DG, Spooren W.

Front Psychiatry. 2016 Nov 29;7:188. eCollection 2016.

9.

Identification and validation of biomarkers for autism spectrum disorders.

Loth E, Spooren W, Ham LM, Isaac MB, Auriche-Benichou C, Banaschewski T, Baron-Cohen S, Broich K, Bölte S, Bourgeron T, Charman T, Collier D, de Andres-Trelles F, Durston S, Ecker C, Elferink A, Haberkamp M, Hemmings R, Johnson MH, Jones EJ, Khwaja OS, Lenton S, Mason L, Mantua V, Meyer-Lindenberg A, Lombardo MV, O'Dwyer L, Okamoto K, Pandina GJ, Pani L, Persico AM, Simonoff E, Tauscher-Wisniewski S, Llinares-Garcia J, Vamvakas S, Williams S, Buitelaar JK, Murphy DG.

Nat Rev Drug Discov. 2016 Jan;15(1):70-3. doi: 10.1038/nrd.2015.7. No abstract available.

PMID:
26718285
10.

New treatment targets for autism spectrum disorders: EU-AIMS.

Loth E, Spooren W, Murphy DG; EU-AIMS consortium.

Lancet Psychiatry. 2014 Nov;1(6):413-5. doi: 10.1016/S2215-0366(14)00004-2. Epub 2014 Nov 5. No abstract available.

PMID:
26361185
11.

Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder.

Brunner D, Kabitzke P, He D, Cox K, Thiede L, Hanania T, Sabath E, Alexandrov V, Saxe M, Peles E, Mills A, Spooren W, Ghosh A, Feliciano P, Benedetti M, Luo Clayton A, Biemans B.

PLoS One. 2015 Aug 14;10(8):e0134572. doi: 10.1371/journal.pone.0134572. eCollection 2015.

12.

Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression.

Lindemann L, Porter RH, Scharf SH, Kuennecke B, Bruns A, von Kienlin M, Harrison AC, Paehler A, Funk C, Gloge A, Schneider M, Parrott NJ, Polonchuk L, Niederhauser U, Morairty SR, Kilduff TS, Vieira E, Kolczewski S, Wichmann J, Hartung T, Honer M, Borroni E, Moreau JL, Prinssen E, Spooren W, Wettstein JG, Jaeschke G.

J Pharmacol Exp Ther. 2015 Apr;353(1):213-33. doi: 10.1124/jpet.114.222463. Epub 2015 Feb 9.

13.

Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

Jaeschke G, Kolczewski S, Spooren W, Vieira E, Bitter-Stoll N, Boissin P, Borroni E, Büttelmann B, Ceccarelli S, Clemann N, David B, Funk C, Guba W, Harrison A, Hartung T, Honer M, Huwyler J, Kuratli M, Niederhauser U, Pähler A, Peters JU, Petersen A, Prinssen E, Ricci A, Rueher D, Rueher M, Schneider M, Spurr P, Stoll T, Tännler D, Wichmann J, Porter RH, Wettstein JG, Lindemann L.

J Med Chem. 2015 Feb 12;58(3):1358-71. doi: 10.1021/jm501642c. Epub 2015 Feb 2.

PMID:
25565255
14.

European clinical network: autism spectrum disorder assessments and patient characterisation.

Ashwood KL, Buitelaar J, Murphy D, Spooren W, Charman T.

Eur Child Adolesc Psychiatry. 2015 Aug;24(8):985-95. doi: 10.1007/s00787-014-0648-2. Epub 2014 Dec 4.

PMID:
25471824
15.

Public-private partnership: a new engine for translational research in neurosciences.

Murphy DG, Goldman M, Loth E, Spooren W.

Neuron. 2014 Nov 5;84(3):533-6. doi: 10.1016/j.neuron.2014.10.006. Epub 2014 Nov 5.

16.

Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: biochemical and electrophysiological characterization.

Malherbe P, Knoflach F, Marcuz A, Bohnert C, Weber M, Knust H, Ratni H, Spooren W, Ballard TM, Bissantz C.

Neuropharmacology. 2014 Nov;86:259-72. doi: 10.1016/j.neuropharm.2014.07.017. Epub 2014 Aug 5.

PMID:
25107588
17.

Alexander Rudolf Cools (1942-2013).

Ellenbroek BA, Homberg J, Verheij M, Spooren W, van den Bos R, Martens G.

Psychopharmacology (Berl). 2014 Jun;231(11):2219-22. doi: 10.1007/s00213-014-3583-5. Epub 2014 Apr 26. No abstract available.

PMID:
24770629
18.

Autism spectrum disorders--an emerging area in psychopharmacology.

Steckler T, Spooren W, Murphy D.

Psychopharmacology (Berl). 2014 Mar;231(6):977-8. doi: 10.1007/s00213-014-3460-2. No abstract available.

PMID:
24481571
19.

Using genetic findings in autism for the development of new pharmaceutical compounds.

Vorstman JA, Spooren W, Persico AM, Collier DA, Aigner S, Jagasia R, Glennon JC, Buitelaar JK.

Psychopharmacology (Berl). 2014 Mar;231(6):1063-78. doi: 10.1007/s00213-013-3334-z. Epub 2013 Nov 30. Review.

PMID:
24292384
20.

Developing new pharmacotherapies for autism.

Ecker C, Spooren W, Murphy D.

J Intern Med. 2013 Oct;274(4):308-20. doi: 10.1111/joim.12113. Epub 2013 Aug 10. Review.

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