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Acta Neurochir (Wien). 2015 Apr;157(4):597-605; discussion 605. doi: 10.1007/s00701-014-2340-1. Epub 2015 Jan 16.

Solitary lesions of the clivus: what else besides chordomas? An extensive clinical outlook on rare pathologies.

Author information

1
Department of Neurosurgery and Gamma Knife Radiosurgery, San Raffaele Scientific Institute, Vita-Salute University, Via Olgettina 60, 20132, Milan, Italy, gagliardi.filippo@hsr.it.

Abstract

BACKGROUND:

Solitary non-chordomatous lesions of the clivus are rare pathologies, which represent a diagnostic challenge. This study provides an overview of the clinical, radiological and prognostic characteristics of non-chordomatous clival lesions, highlighting current therapeutic options.

METHODS:

Twenty-two non-chordomatous lesions of the clivus were collected. A retrospective analysis of clinical and radiological patterns as well as survival data was conducted.

RESULTS:

Clinical presentation was a result of local mass effect. Imaging features, although mainly specific, were not always diagnostic. Extent of surgery was gross total in 45.5 % of cases. Depending on the histology, biological behaviour and presence of seeding, adjuvant treatment was performed, tailoring the treatment strategy to the single patient.

CONCLUSIONS:

Solitary non-chordomatous lesions of the clival bone are more prevalent than expected. They should be approached with a correct differential diagnosis, considering specific epidemiological, radiological, and histopathological characteristics, to minimise diagnostic bias and allow the planning of the best treatment strategy.

PMID:
25591803
DOI:
10.1007/s00701-014-2340-1
[Indexed for MEDLINE]

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