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J Org Chem. 2004 Oct 1;69(20):6900-3.

Solid-phase chemoenzymatic synthesis of C-sialosides.

Author information

1
Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.

Abstract

The chemoenzymatic regioselective acylation of Neu5Ac followed by SmI2-mediated C-glycosylation on a solid support is described for five C-glycosides. This method should facilitate the construction of combinatorial libraries of inhibitors of neuraminidase activity and hemagglutinin interaction as potential antiviral agents.

PMID:
15387620
PMCID:
PMC4135478
DOI:
10.1021/jo0491298
[Indexed for MEDLINE]
Free PMC Article

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