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Items: 1 to 20 of 71

1.

Improving the odds of drug development success through human genomics: modelling study.

Hingorani AD, Kuan V, Finan C, Kruger FA, Gaulton A, Chopade S, Sofat R, MacAllister RJ, Overington JP, Hemingway H, Denaxas S, Prieto D, Casas JP.

Sci Rep. 2019 Dec 11;9(1):18911. doi: 10.1038/s41598-019-54849-w.

PMID:
31827124
2.

Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis.

Pasea L, Chung SC, Pujades-Rodriguez M, Shah AD, Alvarez-Madrazo S, Allan V, Teo JT, Bean D, Sofat R, Dobson R, Banerjee A, Patel RS, Timmis A, Denaxas S, Hemingway H.

BMC Med. 2019 Nov 20;17(1):206. doi: 10.1186/s12916-019-1438-y.

3.

A novel approach to support implementation of biosimilars within a UK tertiary hospital.

Saxby K, Sanghvi S, Bodalia PN, Ferner RE, Leandro M, Urquhart R, Sofat R.

Br J Clin Pharmacol. 2019 Oct 29. doi: 10.1111/bcp.14150. [Epub ahead of print]

PMID:
31663154
4.

A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service.

Kuan V, Denaxas S, Gonzalez-Izquierdo A, Direk K, Bhatti O, Husain S, Sutaria S, Hingorani M, Nitsch D, Parisinos CA, Lumbers RT, Mathur R, Sofat R, Casas JP, Wong ICK, Hemingway H, Hingorani AD.

Lancet Digit Health. 2019 May 20;1(2):e63-e77. doi: 10.1016/S2589-7500(19)30012-3. eCollection 2019 Jun.

5.

Drug and therapeutics committees as guardians of safe and rational medicines use.

Sofat R, Cremers S, Ferner RE.

Br J Clin Pharmacol. 2019 Oct 18. doi: 10.1111/bcp.14088. [Epub ahead of print] No abstract available.

PMID:
31625180
6.

Evaluation of cardiovascular risk in a lung cancer screening cohort.

Ruparel M, Quaife SL, Dickson JL, Horst C, Burke S, Taylor M, Ahmed A, Shaw P, Soo MJ, Nair A, Devaraj A, O'Dowd EL, Bhowmik A, Navani N, Sennett K, Duffy SW, Baldwin DR, Sofat R, Patel RS, Hingorani A, Janes SM.

Thorax. 2019 Dec;74(12):1140-1146. doi: 10.1136/thoraxjnl-2018-212812. Epub 2019 Sep 26.

7.

Directly Acting Oral Anticoagulants for the Prevention of Stroke in Atrial Fibrillation in England and Wales: Cost-Effectiveness Model and Value of Information Analysis.

Thom HHZ, Hollingworth W, Sofat R, Wang Z, Fang W, Bodalia PN, Bryden PA, Davies PA, Caldwell DM, Dias S, Eaton D, Higgins JPT, Hingorani AD, Lopez-Lopez JA, Okoli GN, Richards A, Salisbury C, Savović J, Stephens-Boal A, Sterne JAC, Welton NJ.

MDM Policy Pract. 2019 Aug 17;4(2):2381468319866828. doi: 10.1177/2381468319866828. eCollection 2019 Jul-Dec.

8.

Eligibility and subsequent burden of cardiovascular disease of four strategies for blood pressure-lowering treatment: a retrospective cohort study.

Herrett E, Gadd S, Jackson R, Bhaskaran K, Williamson E, van Staa T, Sofat R, Timmis A, Smeeth L.

Lancet. 2019 Aug 24;394(10199):663-671. doi: 10.1016/S0140-6736(19)31359-5. Epub 2019 Jul 25.

9.

24-Hour vs. Spot Urinary Sodium and Potassium Measurements in Adult Hypertensive Patients: A Cohort Validation Study.

Wan ER, Cross J, Sofat R, Walsh SB.

Am J Hypertens. 2019 Sep 24;32(10):983-991. doi: 10.1093/ajh/hpz104.

PMID:
31247068
10.

Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial.

Hobbs AJ, Moyes AJ, Baliga RS, Ghedia D, Ochiel R, Sylvestre Y, Doré CJ, Chowdhury K, Maclagan K, Quartly HL, Sofat R, Smit A, Schreiber BE, Coghlan GJ, MacAllister RJ.

Br J Pharmacol. 2019 May;176(9):1251-1267. doi: 10.1111/bph.14621. Epub 2019 Mar 31.

PMID:
30761523
11.

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

Chauhan G, Adams HHH, Satizabal CL, Bis JC, Teumer A, Sargurupremraj M, Hofer E, Trompet S, Hilal S, Smith AV, Jian X, Malik R, Traylor M, Pulit SL, Amouyel P, Mazoyer B, Zhu YC, Kaffashian S, Schilling S, Beecham GW, Montine TJ, Schellenberg GD, Kjartansson O, Guðnason V, Knopman DS, Griswold ME, Windham BG, Gottesman RF, Mosley TH, Schmidt R, Saba Y, Schmidt H, Takeuchi F, Yamaguchi S, Nabika T, Kato N, Rajan KB, Aggarwal NT, De Jager PL, Evans DA, Psaty BM, Rotter JI, Rice K, Lopez OL, Liao J, Chen C, Cheng CY, Wong TY, Ikram MK, van der Lee SJ, Amin N, Chouraki V, DeStefano AL, Aparicio HJ, Romero JR, Maillard P, DeCarli C, Wardlaw JM, Hernández MDCV, Luciano M, Liewald D, Deary IJ, Starr JM, Bastin ME, Muñoz Maniega S, Slagboom PE, Beekman M, Deelen J, Uh HW, Lemmens R, Brodaty H, Wright MJ, Ames D, Boncoraglio GB, Hopewell JC, Beecham AH, Blanton SH, Wright CB, Sacco RL, Wen W, Thalamuthu A, Armstrong NJ, Chong E, Schofield PR, Kwok JB, van der Grond J, Stott DJ, Ford I, Jukema JW, Vernooij MW, Hofman A, Uitterlinden AG, van der Lugt A, Wittfeld K, Grabe HJ, Hosten N, von Sarnowski B, Völker U, Levi C, Jimenez-Conde J, Sharma P, Sudlow CLM, Rosand J, Woo D, Cole JW, Meschia JF, Slowik A, Thijs V, Lindgren A, Melander O, Grewal RP, Rundek T, Rexrode K, Rothwell PM, Arnett DK, Jern C, Johnson JA, Benavente OR, Wasssertheil-Smoller S, Lee JM, Wong Q, Mitchell BD, Rich SS, McArdle PF, Geerlings MI, van der Graaf Y, de Bakker PIW, Asselbergs FW, Srikanth V, Thomson R, McWhirter R, Moran C, Callisaya M, Phan T, Rutten-Jacobs LCA, Bevan S, Tzourio C, Mather KA, Sachdev PS, van Duijn CM, Worrall BB, Dichgans M, Kittner SJ, Markus HS, Ikram MA, Fornage M, Launer LJ, Seshadri S, Longstreth WT Jr, Debette S; Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium.

Neurology. 2019 Jan 16. pii: 10.1212/WNL.0000000000006851. doi: 10.1212/WNL.0000000000006851. [Epub ahead of print]

12.

Mendelian randomization study shows no causal relationship between circulating urate levels and Parkinson's disease.

Kia DA, Noyce AJ, White J, Speed D, Nicolas A; IPDGC collaborators, Burgess S, Lawlor DA, Davey Smith G, Singleton A, Nalls MA, Sofat R, Wood NW.

Ann Neurol. 2018 Aug;84(2):191-199. doi: 10.1002/ana.25294.

13.

Resistant Hypertension: Trials and Tribulations.

George MJ, Marks DJB, Rezk T, Breckenridge R, Sofat R, Martin J, MacAllister R, Touyz RM, Staessen JA, Bursztyn M, Lappin D, Barigou M, Hingorani A.

Hypertension. 2018 May;71(5):772-780. doi: 10.1161/HYPERTENSIONAHA.118.10864. Epub 2018 Apr 2. Review. No abstract available.

PMID:
29610269
14.

Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study.

Brinkman DJ, Tichelaar J, Mokkink LB, Christiaens T, Likic R, Maciulaitis R, Costa J, Sanz EJ, Maxwell SR, Richir MC, van Agtmael MA; Education Working Group of the European Association for Clinical Pharmacology and Therapeutics (EACPT) and its affiliated Network of Teachers in Pharmacotherapy (NOTIP).

Clin Pharmacol Ther. 2018 Aug;104(2):317-325. doi: 10.1002/cpt.962. Epub 2018 Jan 30.

15.

Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis.

López-López JA, Sterne JAC, Thom HHZ, Higgins JPT, Hingorani AD, Okoli GN, Davies PA, Bodalia PN, Bryden PA, Welton NJ, Hollingworth W, Caldwell DM, Savović J, Dias S, Salisbury C, Eaton D, Stephens-Boal A, Sofat R.

BMJ. 2017 Nov 28;359:j5058. doi: 10.1136/bmj.j5058. Review. Erratum in: BMJ. 2017 Dec 4;359:j5631. BMJ. 2018 May 23;361:k2295.

16.

Cross-talk between iNKT cells and monocytes triggers an atheroprotective immune response in SLE patients with asymptomatic plaque.

Smith E, Croca S, Waddington KE, Sofat R, Griffin M, Nicolaides A, Isenberg DA, Torra IP, Rahman A, Jury EC.

Sci Immunol. 2016 Dec 2;1(6). pii: eaah4081. doi: 10.1126/sciimmunol.aah4081.

PMID:
28783690
17.

Association of C-Reactive Protein Genetic Polymorphisms With Late Age-Related Macular Degeneration.

Cipriani V, Hogg RE, Sofat R, Moore AT, Webster AR, Yates JRW, Fletcher AE; European Eye (EUREYE) Study Group.

JAMA Ophthalmol. 2017 Sep 1;135(9):909-916. doi: 10.1001/jamaophthalmol.2017.2191.

18.

Screening strategies for atrial fibrillation: a systematic review and cost-effectiveness analysis.

Welton NJ, McAleenan A, Thom HH, Davies P, Hollingworth W, Higgins JP, Okoli G, Sterne JA, Feder G, Eaton D, Hingorani A, Fawsitt C, Lobban T, Bryden P, Richards A, Sofat R.

Health Technol Assess. 2017 May;21(29):1-236. doi: 10.3310/hta21290. Review.

19.

Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis.

Dale CE, Fatemifar G, Palmer TM, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T, Wong A, Warren HR, McLachlan S, Trompet S, Moldovan M, Morris RW, Sofat R, Kumari M, Hyppönen E, Jefferis BJ, Gaunt TR, Ben-Shlomo Y, Zhou A, Gentry-Maharaj A, Ryan A; UCLEB Consortium; METASTROKE Consortium, Mutsert R, Noordam R, Caulfield MJ, Jukema JW, Worrall BB, Munroe PB, Menon U, Power C, Kuh D, Lawlor DA, Humphries SE, Mook-Kanamori DO, Sattar N, Kivimaki M, Price JF, Davey Smith G, Dudbridge F, Hingorani AD, Holmes MV, Casas JP.

Circulation. 2017 Jun 13;135(24):2373-2388. doi: 10.1161/CIRCULATIONAHA.116.026560. Epub 2017 May 12.

20.

Oral anticoagulants for primary prevention, treatment and secondary prevention of venous thromboembolic disease, and for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis and cost-effectiveness analysis.

Sterne JA, Bodalia PN, Bryden PA, Davies PA, López-López JA, Okoli GN, Thom HH, Caldwell DM, Dias S, Eaton D, Higgins JP, Hollingworth W, Salisbury C, Savović J, Sofat R, Stephens-Boal A, Welton NJ, Hingorani AD.

Health Technol Assess. 2017 Mar;21(9):1-386. doi: 10.3310/hta21090. Review.

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