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See 1 citation in Sleep Med 2014:

Sleep Med. 2014 Oct;15(10):1241-5. doi: 10.1016/j.sleep.2014.05.011. Epub 2014 Jun 13.

Medications associated with restless legs syndrome: a case-control study in the US Renal Data System (USRDS).

Author information

1
United States Renal Data System Rehabilitation/Quality of Life Special Studies Center and Department of Neurology, Emory University, Atlanta, GA, USA. Electronic address: dbliwis@emory.edu.
2
United States Renal Data System Rehabilitation/Quality of Life Special Studies Center and Department of Neurology, Emory University, Atlanta, GA, USA.

Abstract

OBJECTIVE:

The objective of this study was to determine the association between the usage of four classes of "at-risk" medications (antidepressants, neuroleptics, antihistamines, and antiemetics with dopamine blockade) and restless legs syndrome (RLS) in dialysis patients within the United States Renal Data System (USRDS).

METHODS:

This was a case-control design within a national (United States) patient registry of all patients with end-stage renal disease (ESRD) in the USRDS anytime during the period of 1 October 2006 to 31 December 2010, inclusive. A total of 16,165 ESRD patients (3234 cases; 12,931 age-, sex-, and race-matched controls) were studied.

RESULTS:

All four classes of "at-risk" medications see widespread use among patients in the USRDS. All were associated with increased odds of an RLS diagnosis (range of odds ratios, 1.47-2.28; all p < 0.0001) during the period of observation. Results were unchanged when controlling for time on hemodialysis. Usage of more than one class of medication increased the odds for having RLS.

CONCLUSIONS:

ESRD patients often receive medication intended for relief of conditions associated with their disease, such as depression and psychological issues, pruritus, and gastroparesis; however, such medications may increase the risk of RLS. Given the high prevalence of RLS in ESRD patients, these medications should only be used when their benefits clearly outweigh the risk of development of the troubling and distressing symptoms of RLS.

KEYWORDS:

Case–control design; Chronic kidney disease; Dialysis; End-stage renal disease; Medications; Restless legs syndrome

PMID:
25156752
PMCID:
PMC4172448
DOI:
10.1016/j.sleep.2014.05.011
[Indexed for MEDLINE]
Free PMC Article

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