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Items: 1 to 20 of 116


DJ-1 modulates the unfolded protein response and cell death via upregulation of ATF4 following ER stress.

Yang J, Kim KS, Iyirhiaro GO, Marcogliese PC, Callaghan SM, Qu D, Kim WJ, Slack RS, Park DS.

Cell Death Dis. 2019 Feb 12;10(2):135. doi: 10.1038/s41419-019-1354-2.


Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP.

Boonying W, Joselin A, Huang E, Qu D, Safarpour F, Iyirhiaro GO, Rodriguez Gonzalez Y, Callaghan SM, Slack RS, Figeys D, Chung YH, Park DS.

J Neurochem. 2019 Feb 8. doi: 10.1111/jnc.14683. [Epub ahead of print]


Mitochondria as central regulators of neural stem cell fate and cognitive function.

Khacho M, Harris R, Slack RS.

Nat Rev Neurosci. 2019 Jan;20(1):34-48. doi: 10.1038/s41583-018-0091-3. Review.


Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.

Kim KS, Marcogliese PC, Yang J, Callaghan SM, Resende V, Abdel-Messih E, Marras C, Visanji NP, Huang J, Schlossmacher MG, Trinkle-Mulcahy L, Slack RS, Lang AE; Canadian Lrrk2 in Inflammation Team (CLINT), Park DS.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5164-E5173. doi: 10.1073/pnas.1718946115. Epub 2018 May 14.


Comparative analysis of Parkinson's disease-associated genes in mice reveals altered survival and bioenergetics of Parkin-deficient dopamine neurons.

Giguère N, Pacelli C, Saumure C, Bourque MJ, Matheoud D, Levesque D, Slack RS, Park DS, Trudeau LÉ.

J Biol Chem. 2018 Jun 22;293(25):9580-9593. doi: 10.1074/jbc.RA117.000499. Epub 2018 Apr 26.


Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM.

Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4. Epub 2017 Dec 11. Review.


Mitochondrial activity in the regulation of stem cell self-renewal and differentiation.

Khacho M, Slack RS.

Curr Opin Cell Biol. 2017 Dec;49:1-8. doi: 10.1016/ Epub 2017 Nov 22. Review.


Modeling Neuronal Death and Degeneration in Mouse Primary Cerebellar Granule Neurons.

Laaper M, Haque T, Slack RS, Jahani-Asl A.

J Vis Exp. 2017 Nov 6;(129). doi: 10.3791/55871.


Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism.

Thrush AB, Antoun G, Nikpay M, Patten DA, DeVlugt C, Mauger JF, Beauchamp BL, Lau P, Reshke R, Doucet É, Imbeault P, Boushel R, Gibbings D, Hager J, Valsesia A, Slack RS, Al-Dirbashi OY, Dent R, McPherson R, Harper ME.

Int J Obes (Lond). 2018 Mar;42(3):353-362. doi: 10.1038/ijo.2017.286. Epub 2017 Nov 20.


PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress.

Huang E, Qu D, Huang T, Rizzi N, Boonying W, Krolak D, Ciana P, Woulfe J, Klein C, Slack RS, Figeys D, Park DS.

Nat Commun. 2017 Nov 9;8(1):1399. doi: 10.1038/s41467-017-01435-1.


Mitochondrial and Reactive Oxygen Species Signaling Coordinate Stem Cell Fate Decisions and Life Long Maintenance.

Khacho M, Slack RS.

Antioxid Redox Signal. 2017 Jul 31. doi: 10.1089/ars.2017.7228. [Epub ahead of print]


Mitochondrial dynamics in the regulation of neurogenesis: From development to the adult brain.

Khacho M, Slack RS.

Dev Dyn. 2018 Jan;247(1):47-53. doi: 10.1002/dvdy.24538. Epub 2017 Jul 13. Review.


Cdc25A Is a Critical Mediator of Ischemic Neuronal Death In Vitro and In Vivo.

Iyirhiaro GO, Im DS, Boonying W, Callaghan SM, During MJ, Slack RS, Park DS.

J Neurosci. 2017 Jul 12;37(28):6729-6740. doi: 10.1523/JNEUROSCI.3017-16.2017. Epub 2017 Jun 12.


Mitochondrial dysfunction underlies cognitive defects as a result of neural stem cell depletion and impaired neurogenesis.

Khacho M, Clark A, Svoboda DS, MacLaurin JG, Lagace DC, Park DS, Slack RS.

Hum Mol Genet. 2017 Sep 1;26(17):3327-3341. doi: 10.1093/hmg/ddx217.


RB: An essential player in adult neurogenesis.

Fong BC, Slack RS.

Neurogenesis (Austin). 2017 Feb 7;4(1):e1270382. doi: 10.1080/23262133.2016.1270382. eCollection 2017.


LRRK2(I2020T) functional genetic interactors that modify eye degeneration and dopaminergic cell loss in Drosophila.

Marcogliese PC, Abuaish S, Kabbach G, Abdel-Messih E, Seang S, Li G, Slack RS, Haque ME, Venderova K, Park DS.

Hum Mol Genet. 2017 Apr 1;26(7):1247-1257. doi: 10.1093/hmg/ddx030.


RB regulates the production and the survival of newborn neurons in the embryonic and adult dentate gyrus.

Vandenbosch R, Clark A, Fong BC, Omais S, Jaafar C, Dugal-Tessier D, Dhaliwal J, Lagace DC, Park DS, Ghanem N, Slack RS.

Hippocampus. 2016 Nov;26(11):1379-1392. doi: 10.1002/hipo.22613. Epub 2016 Jul 8.


Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program.

Khacho M, Clark A, Svoboda DS, Azzi J, MacLaurin JG, Meghaizel C, Sesaki H, Lagace DC, Germain M, Harper ME, Park DS, Slack RS.

Cell Stem Cell. 2016 Aug 4;19(2):232-247. doi: 10.1016/j.stem.2016.04.015. Epub 2016 May 26.


Forebrain neurogenesis: From embryo to adult.

Dennis D, Picketts D, Slack RS, Schuurmans C.

Trends Dev Biol. 2016 Jan 1;9(1):77-90.


Erratum to: Impaired mitochondrial oxidative phosphorylation and supercomplex assembly in rectus abdominis muscle of diabetic obese individuals.

Antoun G, McMurray F, Thrush AB, Patten DA, Peixoto AC, Slack RS, McPherson R, Dent R, Harper ME.

Diabetologia. 2016 Feb;59(2):396-7. doi: 10.1007/s00125-015-3821-3. No abstract available.


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